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Atomistry » Chlorine » PDB 4lhu-4lqx » 4li5 » |
Chlorine in PDB 4li5: Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-EnamideEnzymatic activity of Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide
All present enzymatic activity of Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide:
2.7.10.1; Protein crystallography data
The structure of Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide, PDB code: 4li5
was solved by
J.E.Debreczeni,
G.B.Seiffert,
R.Kiefersauer,
M.Augustin,
S.Nagel,
R.Ward,
M.Anderton,
S.Ashton,
P.Bethel,
M.Box,
S.Butterworth,
N.Colclough,
C.Chroley,
C.Chuaqui,
D.Cross,
C.Eberlein,
R.Finlay,
G.Hill,
M.Grist,
T.Klinowska,
C.Lane,
S.Martin,
J.Orme,
P.Smith,
F.Wang,
M.Waring,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4li5:
The structure of Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide
(pdb code 4li5). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide, PDB code: 4li5: Chlorine binding site 1 out of 1 in 4li5Go back to Chlorine Binding Sites List in 4li5
Chlorine binding site 1 out
of 1 in the Egfr-K in Complex with N-[3-[[5-Chloro-4-(1H-Indol-3-Yl)Pyrimidin-2- Yl]Amino]-4-Methoxy-Phenyl] Prop-2-Enamide
Mono view Stereo pair view
Reference:
R.A.Ward,
M.J.Anderton,
S.Ashton,
P.A.Bethel,
M.Box,
S.Butterworth,
N.Colclough,
C.G.Chorley,
C.Chuaqui,
D.A.Cross,
L.A.Dakin,
J.E.Debreczeni,
C.Eberlein,
M.R.Finlay,
G.B.Hill,
M.Grist,
T.C.Klinowska,
C.Lane,
S.Martin,
J.P.Orme,
P.Smith,
F.Wang,
M.J.Waring.
Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (Egfr). J.Med.Chem. V. 56 7025 2013.
Page generated: Sat Dec 12 10:52:59 2020
ISSN: ISSN 0022-2623 PubMed: 23930994 DOI: 10.1021/JM400822Z |
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