Chlorine in PDB 4lmk: Glic Liganded-Closed-Channel Conformation, Mutant Y27'A

The structure of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A, PDB code: 4lmk was solved by C.Grosman, G.Gonzalez-Gutierrez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.76 / 3.22
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	180.990, 134.280, 159.940, 90.00, 102.06, 90.00
R / Rfree (%)	21.1 / 23.8

The structure of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A also contains other interesting chemical elements:

Sodium

(Na)

5 atoms

The binding sites of Chlorine atom in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A (pdb code 4lmk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A, PDB code: 4lmk:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:65.7 occ:1.00 N A:TYR220 3.5 22.6 1.0 CB A:TYR220 4.1 30.3 1.0 CA A:SER219 4.2 30.1 1.0 OG A:SER219 4.2 42.4 1.0 C A:SER219 4.3 36.2 1.0 CA A:TYR220 4.3 22.7 1.0 N A:GLU221 4.5 27.1 1.0 CB A:SER219 4.7 35.2 1.0 O A:THR218 4.8 52.8 1.0 C A:TYR220 4.9 28.3 1.0

Chlorine binding site 2 out of 5 in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl403 b:62.3 occ:1.00 N E:TYR220 3.3 26.2 1.0 CB E:TYR220 3.8 30.5 1.0 CA E:TYR220 4.1 23.0 1.0 CA E:SER219 4.2 25.2 1.0 C E:SER219 4.2 35.1 1.0 N E:GLU221 4.5 31.8 1.0 OG E:SER219 4.5 44.3 1.0 O E:THR218 4.5 47.3 1.0 C E:TYR220 4.9 33.1 1.0 CD2 E:HIS276 4.9 32.8 1.0 CB E:SER219 4.9 30.7 1.0

Chlorine binding site 3 out of 5 in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl401 b:64.9 occ:1.00 N C:TYR220 3.2 21.0 1.0 CB C:TYR220 3.8 31.9 1.0 CA C:SER219 3.9 25.0 1.0 C C:SER219 4.0 28.7 1.0 CA C:TYR220 4.0 20.1 1.0 OG C:SER219 4.3 40.8 1.0 O C:THR218 4.4 46.0 1.0 N C:GLU221 4.4 26.8 1.0 CB C:SER219 4.6 29.6 1.0 C C:TYR220 4.7 27.1 1.0 CD2 C:HIS276 5.0 27.8 1.0

Chlorine binding site 4 out of 5 in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl403 b:80.5 occ:1.00 N B:TYR220 3.1 27.1 1.0 CA B:SER219 3.7 26.3 1.0 OG B:SER219 3.7 51.4 1.0 C B:SER219 3.8 33.7 1.0 CB B:TYR220 4.0 31.5 1.0 CA B:TYR220 4.0 23.5 1.0 N B:GLU221 4.1 26.4 1.0 CB B:SER219 4.2 30.2 1.0 O B:THR218 4.5 47.8 1.0 C B:TYR220 4.6 29.3 1.0 O B:SER219 4.9 37.3 1.0 N B:SER219 4.9 25.6 1.0

Chlorine binding site 5 out of 5 in the Glic Liganded-Closed-Channel Conformation, Mutant Y27'A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Glic Liganded-Closed-Channel Conformation, Mutant Y27'A within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl402 b:47.3 occ:1.00 N D:TYR220 3.1 27.6 1.0 CA D:SER219 3.8 26.2 1.0 C D:SER219 3.9 35.8 1.0 CB D:TYR220 3.9 31.4 1.0 OG D:SER219 4.0 48.7 1.0 CA D:TYR220 4.0 22.4 1.0 N D:GLU221 4.2 27.7 1.0 CB D:SER219 4.4 29.0 1.0 O D:THR218 4.5 46.3 1.0 C D:TYR220 4.7 29.8 1.0 N D:SER219 5.0 28.3 1.0

G.Gonzalez-Gutierrez, L.G.Cuello, S.K.Nair, C.Grosman. Gating of the Proton-Gated Ion Channel From Gloeobacter Violaceus at pH 4 As Revealed By X-Ray Crystallography. Proc.Natl.Acad.Sci.Usa V. 110 18716 2013.
ISSN: ISSN 0027-8424
PubMed: 24167270
DOI: 10.1073/PNAS.1313156110