Chlorine in PDB 4m48: X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism

The structure of X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism, PDB code: 4m48 was solved by E.Gouaux, A.Penmatsa, K.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.38 / 2.96
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	97.839, 133.684, 162.443, 90.00, 90.00, 90.00
R / Rfree (%)	22.1 / 25.6

The structure of X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism (pdb code 4m48). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism, PDB code: 4m48:

Chlorine binding site 1 out of 1 in the X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl703 b:76.9 occ:1.00 OG A:SER356 2.9 70.4 1.0 OH A:TYR69 3.0 82.2 1.0 OG A:SER320 3.1 71.4 1.0 NE2 A:GLN316 3.1 79.3 1.0 CB A:SER320 3.6 70.5 1.0 CB A:SER356 3.7 72.0 1.0 CB A:PHE53 4.0 74.6 1.0 CZ A:TYR69 4.0 80.7 1.0 CD1 A:PHE53 4.0 80.6 1.0 CD A:GLN316 4.1 77.8 1.0 ND2 A:ASN49 4.1 72.2 1.0 CG A:GLN316 4.2 79.5 1.0 CG A:PHE53 4.2 78.7 1.0 CE1 A:TYR69 4.2 81.9 1.0 ND2 A:ASN352 4.4 80.2 1.0 CG A:ASN49 4.8 71.5 1.0 CE1 A:PHE53 4.8 75.5 1.0 CA A:ASN49 4.8 67.4 1.0 O A:GLN316 4.9 65.0 1.0

A.Penmatsa, K.H.Wang, E.Gouaux. X-Ray Structure of Dopamine Transporter Elucidates Antidepressant Mechanism. Nature V. 503 85 2013.
ISSN: ISSN 0028-0836
PubMed: 24037379
DOI: 10.1038/NATURE12533