Chlorine in PDB 4mcp: A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid)

Enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid)

All present enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid):
3.4.17.21;

Protein crystallography data

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid), PDB code: 4mcp was solved by M.Navratil, C.Barinka, J.Lubkowski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.00 / 1.65
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	101.533, 130.176, 158.809, 90.00, 90.00, 90.00
*R / R_free (%)*	15 / 16.4

Other elements in 4mcp:

Calcium	(Ca)	1 atom
Zinc	(Zn)	2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid) (pdb code 4mcp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid), PDB code: 4mcp:

Chlorine binding site 1 out of 1 in 4mcp

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Chlorine Binding Sites List in 4mcp

Chlorine binding site 1 out of 1 in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid)

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyl-Gamma-L-Glutamic Acid (Pteroyldi-Gamma- L-Glutamic Acid) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl804 b:23.5 occ:1.00	O	A:HOH921	3.2	21.1	1.0
	ND2	A:ASN451	3.3	18.3	1.0
	NH2	A:ARG536	3.4	20.4	0.5
	N	A:ASP453	3.4	19.5	1.0
	NE	A:ARG534	3.4	27.7	1.0
	NH1	A:ARG534	3.4	26.0	1.0
	CB	A:ASP453	3.8	19.2	1.0
	CB	A:ARG534	3.9	19.7	1.0
	CZ	A:ARG534	3.9	27.9	1.0
	NH2	A:ARG580	4.0	20.0	1.0
	CA	A:ASP453	4.0	20.3	1.0
	CB	A:ASN451	4.1	17.9	1.0
	CG	A:ASN451	4.2	18.6	1.0
	C	A:ASP453	4.2	21.0	1.0
	N	A:ALA452	4.2	18.9	1.0
	CZ	A:ARG536	4.3	23.1	0.5
	O	A:ASP453	4.3	22.1	1.0
	C	A:ASN451	4.4	19.6	1.0
	C	A:ALA452	4.4	20.1	1.0
	CA	A:ALA452	4.4	20.5	1.0
	O	A:ASN451	4.5	20.9	1.0
	CD	A:ARG534	4.5	25.6	1.0
	NE	A:ARG536	4.5	22.8	0.5
	CG	A:ARG534	4.6	21.6	1.0
	CD	A:ARG536	4.6	24.8	0.5
	O	A:SER454	4.7	21.4	1.0
	O	A:HOH1512	4.7	43.0	1.0
	CZ	A:ARG580	4.8	21.9	1.0
	N	A:SER454	4.9	20.0	1.0
	O	A:ALA535	4.9	21.1	1.0
	CA	A:ARG534	4.9	19.4	1.0
	NE	A:ARG536	4.9	23.6	0.5
	CA	A:ASN451	4.9	18.0	1.0
	ND2	A:ASN519	4.9	19.1	1.0
	N	A:ALA535	5.0	20.1	1.0

Reference:

M.Navratil, J.Ptacek, P.Sacha, J.Starkova, J.Lubkowski, C.Barinka, J.Konvalinka. Structural and Biochemical Characterization of the Folyl-Poly-Gamma-L-Glutamate Hydrolyzing Activity of Human Glutamate Carboxypeptidase II. Febs J. V. 281 3228 2014.
ISSN: ISSN 1742-464X
PubMed: 24863754
DOI: 10.1111/FEBS.12857

Page generated: Sat Dec 12 10:55:16 2020

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