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Chlorine in PDB 4mcq: A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

Enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)

All present enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid):
3.4.17.21;

Protein crystallography data

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid), PDB code: 4mcq was solved by M.Navratil, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.96 / 2.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.646, 130.140, 159.867, 90.00, 90.00, 90.00
R / Rfree (%) 13.7 / 17.2

Other elements in 4mcq:

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) (pdb code 4mcq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid), PDB code: 4mcq:

Chlorine binding site 1 out of 1 in 4mcq

Go back to Chlorine Binding Sites List in 4mcq
Chlorine binding site 1 out of 1 in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyldi-Gamma-L-Glutamic Acid (Pteroyltri- Gamma-L-Glutamic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl804

b:24.1
occ:1.00
 O A:HOH921 3.1 19.3 1.0
N A:ASP453 3.3 18.8 1.0
ND2 A:ASN451 3.4 17.4 1.0
NE A:ARG534 3.4 26.6 1.0
NH2 A:ARG536 3.5 20.0 1.0
NH1 A:ARG534 3.5 22.5 1.0
CB A:ASP453 3.8 19.1 1.0
NH2 A:ARG580 3.8 16.9 1.0
CA A:ASP453 3.9 19.1 1.0
CB A:ARG534 3.9 19.4 1.0
CZ A:ARG534 3.9 26.3 1.0
C A:ASP453 4.1 19.2 1.0
CB A:ASN451 4.2 16.5 1.0
O A:ASP453 4.2 19.4 1.0
CG A:ASN451 4.3 16.9 1.0
CZ A:ARG536 4.3 21.4 1.0
C A:ALA452 4.3 19.0 1.0
N A:ALA452 4.3 18.5 1.0
NE A:ARG536 4.4 21.0 1.0
CA A:ALA452 4.4 18.4 1.0
C A:ASN451 4.5 18.5 1.0
O A:SER454 4.5 19.6 1.0
CD A:ARG534 4.6 26.0 1.0
O A:ASN451 4.6 19.0 1.0
N A:SER454 4.6 18.7 1.0
CG A:ARG534 4.7 21.9 1.0
O A:ALA535 4.7 19.5 1.0
CZ A:ARG580 4.7 18.6 1.0
CA A:ARG534 4.9 19.4 1.0
N A:ALA535 4.9 19.6 1.0

Reference:

M.Navratil, J.Ptacek, P.Sacha, J.Starkova, J.Lubkowski, C.Barinka, J.Konvalinka. Structural and Biochemical Characterization of the Folyl-Poly-Gamma-L-Glutamate Hydrolyzing Activity of Human Glutamate Carboxypeptidase II. Febs J. V. 281 3228 2014.
ISSN: ISSN 1742-464X
PubMed: 24863754
DOI: 10.1111/FEBS.12857
Page generated: Sun Jul 21 19:43:29 2024

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