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Chlorine in PDB 4mcr: A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid)

Enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid)

All present enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid):
3.4.17.21;

Protein crystallography data

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid), PDB code: 4mcr was solved by M.Navratil, C.Barinka, J.Lubkowski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.48 / 1.65
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.491, 129.830, 158.811, 90.00, 90.00, 90.00
R / Rfree (%) 13.3 / 16.7

Other elements in 4mcr:

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid) also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid) (pdb code 4mcr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid), PDB code: 4mcr:

Chlorine binding site 1 out of 1 in 4mcr

Go back to Chlorine Binding Sites List in 4mcr
Chlorine binding site 1 out of 1 in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with Folyltri-Gamma-L-Glutamic Acid (Pteroyltetra- Gamma-L-Glutamic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl804

b:22.1
occ:1.00
 O A:HOH921 3.2 18.8 1.0
ND2 A:ASN451 3.4 17.6 1.0
N A:ASP453 3.4 17.1 1.0
NE A:ARG534 3.4 26.6 1.0
NH1 A:ARG534 3.5 24.2 1.0
NH2 A:ARG536 3.5 21.9 1.0
CB A:ASP453 3.8 17.8 1.0
CZ A:ARG534 3.9 25.5 1.0
CB A:ARG534 3.9 17.6 1.0
CA A:ASP453 3.9 16.4 1.0
NH2 A:ARG580 4.0 16.8 1.0
C A:ASP453 4.1 16.6 1.0
CB A:ASN451 4.2 15.8 1.0
CG A:ASN451 4.2 15.4 1.0
O A:ASP453 4.3 18.7 1.0
N A:ALA452 4.3 16.9 1.0
CZ A:ARG536 4.3 23.8 1.0
C A:ALA452 4.4 17.3 1.0
NE A:ARG536 4.4 22.7 1.0
CA A:ALA452 4.4 17.5 1.0
C A:ASN451 4.4 17.2 1.0
O A:SER454 4.6 18.5 1.0
CD A:ARG534 4.6 22.5 1.0
O A:ASN451 4.6 19.6 1.0
CG A:ARG534 4.6 19.7 1.0
N A:SER454 4.8 17.6 1.0
CZ A:ARG580 4.8 17.4 1.0
O A:ALA535 4.8 19.1 1.0
ND2 A:ASN519 4.9 17.8 1.0
CA A:ARG534 4.9 16.5 1.0
N A:ALA535 5.0 17.1 1.0

Reference:

M.Navratil, J.Ptacek, P.Sacha, J.Starkova, J.Lubkowski, C.Barinka, J.Konvalinka. Structural and Biochemical Characterization of the Folyl-Poly-Gamma-L-Glutamate Hydrolyzing Activity of Human Glutamate Carboxypeptidase II. Febs J. V. 281 3228 2014.
ISSN: ISSN 1742-464X
PubMed: 24863754
DOI: 10.1111/FEBS.12857
Page generated: Sat Dec 12 10:55:18 2020

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