Atomistry » Chlorine » PDB 4m5h-4mdq » 4mdk
Atomistry »
  Chlorine »
    PDB 4m5h-4mdq »
      4mdk »

Chlorine in PDB 4mdk: CDC34-Ubiquitin-CC0651 Complex

Enzymatic activity of CDC34-Ubiquitin-CC0651 Complex

All present enzymatic activity of CDC34-Ubiquitin-CC0651 Complex:
6.3.2.19;

Protein crystallography data

The structure of CDC34-Ubiquitin-CC0651 Complex, PDB code: 4mdk was solved by D.F.Ceccarelli, S.Orlicky, M.Tyers, F.Sicheri, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.63 / 2.61
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 55.403, 72.220, 75.912, 71.89, 79.63, 81.61
R / Rfree (%) 20.4 / 25.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the CDC34-Ubiquitin-CC0651 Complex (pdb code 4mdk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the CDC34-Ubiquitin-CC0651 Complex, PDB code: 4mdk:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 1 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:53.9
occ:1.00
 CL28 A:U94201 0.0 53.9 1.0
C26 A:U94201 1.7 52.4 1.0
C25 A:U94201 2.7 54.9 1.0
C27 A:U94201 2.7 52.1 1.0
CE2 A:PHE58 3.5 46.8 1.0
CD2 A:PHE58 3.6 45.8 1.0
CD1 A:TYR53 3.7 41.2 1.0
CG A:TYR53 3.9 51.8 1.0
C24 A:U94201 4.0 55.0 1.0
CG2 A:ILE45 4.0 49.5 1.0
C22 A:U94201 4.0 52.7 1.0
CA A:GLY47 4.0 54.8 1.0
CD2 A:LEU131 4.1 45.1 1.0
CB A:TYR53 4.2 51.0 1.0
CE1 A:TYR53 4.2 40.8 1.0
N A:GLY47 4.3 54.5 1.0
CZ A:PHE58 4.3 48.9 1.0
C23 A:U94201 4.5 52.8 1.0
CG A:PHE58 4.5 46.7 1.0
CG A:LEU131 4.5 47.9 1.0
CD2 A:TYR53 4.6 53.0 1.0
CZ A:TYR53 4.9 50.1 1.0
C A:PHE46 4.9 53.5 1.0
CD A:PRO48 4.9 60.3 1.0

Chlorine binding site 2 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 2 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:54.8
occ:1.00
 CL29 A:U94201 0.0 54.8 1.0
C24 A:U94201 1.7 55.0 1.0
C25 A:U94201 2.7 54.9 1.0
C23 A:U94201 2.7 52.8 1.0
CA E:GLY47 3.7 54.3 1.0
CE1 A:PHE28 3.7 52.5 1.0
C26 A:U94201 4.0 52.4 1.0
CG1 A:ILE128 4.0 46.6 1.0
C22 A:U94201 4.0 52.7 1.0
CD1 A:ILE128 4.1 47.3 1.0
O A:GLU26 4.2 54.0 1.0
O E:GLY47 4.2 55.0 1.0
CG2 A:ILE128 4.3 45.7 1.0
CG A:PRO48 4.3 59.1 1.0
CD1 A:PHE28 4.4 52.1 1.0
C E:GLY47 4.5 54.5 1.0
O A:PHE46 4.5 56.0 1.0
C27 A:U94201 4.5 52.1 1.0
CZ A:PHE28 4.7 51.1 1.0
CB A:ILE128 4.7 44.8 1.0
CD A:PRO48 4.7 60.3 1.0
N E:GLY47 4.8 63.5 1.0
O A:GLY27 4.9 66.8 1.0

Chlorine binding site 3 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 3 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl201

b:49.1
occ:1.00
 CL28 B:U94201 0.0 49.1 1.0
C26 B:U94201 1.7 57.5 1.0
C25 B:U94201 2.7 57.0 1.0
C27 B:U94201 2.7 59.7 1.0
CE2 B:PHE58 3.5 55.4 1.0
CD2 B:PHE58 3.5 55.6 1.0
CD1 B:TYR53 3.7 44.9 1.0
C24 B:U94201 4.0 56.6 1.0
CG B:TYR53 4.0 72.2 1.0
CG2 B:ILE45 4.0 45.5 1.0
C22 B:U94201 4.0 57.9 1.0
CB B:TYR53 4.2 45.7 1.0
CD1 B:LEU131 4.2 46.5 1.0
CA B:GLY47 4.3 48.1 1.0
CE1 B:TYR53 4.3 44.9 1.0
N B:GLY47 4.4 46.1 1.0
CZ B:PHE58 4.5 54.9 1.0
CG B:PHE58 4.5 52.2 1.0
C23 B:U94201 4.5 55.1 1.0
C B:PHE46 4.6 50.5 1.0
O B:PHE46 4.7 53.3 1.0
CD2 B:TYR53 4.7 46.2 1.0
CZ B:TYR53 5.0 55.4 1.0
CD2 B:LEU131 5.0 47.5 1.0

Chlorine binding site 4 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 4 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl201

b:61.4
occ:1.00
 CL29 B:U94201 0.0 61.4 1.0
C24 B:U94201 1.7 56.6 1.0
C25 B:U94201 2.7 57.0 1.0
C23 B:U94201 2.7 55.1 1.0
CA F:GLY47 3.7 59.2 1.0
CE1 B:PHE28 3.8 57.2 1.0
CD1 B:ILE128 3.9 57.5 1.0
C26 B:U94201 4.0 57.5 1.0
O B:PHE46 4.0 53.3 1.0
C22 B:U94201 4.0 57.9 1.0
O F:GLY47 4.2 51.5 1.0
CG B:PRO48 4.2 57.0 1.0
CD1 B:PHE28 4.2 53.5 1.0
CG1 B:ILE128 4.2 52.4 1.0
O B:GLU26 4.3 56.8 1.0
CA B:GLY27 4.3 53.3 1.0
CD B:PRO48 4.4 55.4 1.0
C F:GLY47 4.5 60.5 1.0
C27 B:U94201 4.5 59.7 1.0
CG2 B:ILE128 4.5 47.1 1.0
C B:GLY27 4.8 52.3 1.0
N F:GLY47 4.9 63.1 1.0
CG2 B:ILE45 4.9 45.5 1.0
CZ B:PHE28 4.9 58.3 1.0
O B:GLY27 5.0 53.6 1.0
CB B:ILE128 5.0 50.7 1.0

Chlorine binding site 5 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 5 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl201

b:54.4
occ:1.00
 CL28 C:U94201 0.0 54.4 1.0
C26 C:U94201 1.7 51.9 1.0
C25 C:U94201 2.7 51.7 1.0
C27 C:U94201 2.7 54.1 1.0
CE2 C:PHE58 3.5 47.5 1.0
CD2 C:PHE58 3.6 49.2 1.0
CG2 C:ILE45 3.9 46.0 1.0
CD1 C:TYR53 4.0 37.5 1.0
C24 C:U94201 4.0 53.4 1.0
C22 C:U94201 4.0 53.8 1.0
CA C:GLY47 4.1 51.9 1.0
CG C:TYR53 4.1 41.6 1.0
CD2 C:LEU131 4.2 46.6 1.0
N C:GLY47 4.3 55.6 1.0
CZ C:PHE58 4.3 44.9 1.0
CB C:TYR53 4.3 45.6 1.0
CG C:PHE58 4.4 47.9 1.0
CE1 C:TYR53 4.4 42.4 1.0
C23 C:U94201 4.5 53.9 1.0
C C:PHE46 4.7 56.4 1.0
CD2 C:TYR53 4.7 43.3 1.0
CG C:LEU131 4.8 47.0 1.0
O C:PHE46 4.8 59.9 1.0
CD C:PRO48 4.9 54.8 1.0
CE1 C:PHE58 5.0 45.6 1.0

Chlorine binding site 6 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 6 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl201

b:61.5
occ:1.00
 CL29 C:U94201 0.0 61.5 1.0
C24 C:U94201 1.7 53.4 1.0
C25 C:U94201 2.7 51.7 1.0
C23 C:U94201 2.7 53.9 1.0
CA G:GLY47 3.6 64.3 1.0
CG C:PRO48 3.8 53.8 1.0
O G:GLY47 3.9 67.9 1.0
C26 C:U94201 4.0 51.9 1.0
C22 C:U94201 4.0 53.8 1.0
CE1 C:PHE28 4.0 50.9 1.0
CD1 C:ILE128 4.1 45.8 1.0
CG1 C:ILE128 4.2 46.2 1.0
C G:GLY47 4.3 65.6 1.0
CD C:PRO48 4.3 54.8 1.0
CG2 C:ILE128 4.3 39.7 1.0
O C:GLU26 4.3 74.4 1.0
O C:PHE46 4.4 59.9 1.0
C27 C:U94201 4.5 54.1 1.0
CD1 C:PHE28 4.6 56.9 1.0
N G:GLY47 4.8 65.8 1.0
CB C:ILE128 4.8 45.0 1.0
CA C:GLY27 5.0 75.5 1.0

Chlorine binding site 7 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 7 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl201

b:55.0
occ:1.00
 CL28 D:U94201 0.0 55.0 1.0
C26 D:U94201 1.7 73.0 1.0
C27 D:U94201 2.7 72.4 1.0
C25 D:U94201 2.7 72.4 1.0
CE2 D:PHE58 3.5 49.3 1.0
CD2 D:PHE58 3.6 50.5 1.0
CG2 D:ILE45 3.7 55.4 1.0
CD1 D:TYR53 3.9 55.9 1.0
C22 D:U94201 4.0 69.1 1.0
C24 D:U94201 4.0 73.2 1.0
CA D:GLY47 4.0 50.0 1.0
CD2 D:LEU131 4.1 58.7 1.0
CG D:TYR53 4.1 56.6 1.0
CB D:TYR53 4.2 55.0 1.0
N D:GLY47 4.2 53.5 1.0
CZ D:PHE58 4.4 49.5 1.0
C D:PHE46 4.5 54.6 1.0
C23 D:U94201 4.5 70.0 1.0
O D:PHE46 4.5 56.4 1.0
CG D:PHE58 4.6 48.5 1.0
CE1 D:TYR53 4.6 54.3 1.0
CG D:LEU131 4.8 61.8 1.0
CD2 D:TYR53 4.9 56.0 1.0
CB D:ILE45 4.9 61.0 1.0

Chlorine binding site 8 out of 8 in 4mdk

Go back to Chlorine Binding Sites List in 4mdk
Chlorine binding site 8 out of 8 in the CDC34-Ubiquitin-CC0651 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of CDC34-Ubiquitin-CC0651 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl201

b:59.1
occ:1.00
 CL29 D:U94201 0.0 59.1 1.0
C24 D:U94201 1.7 73.2 1.0
C25 D:U94201 2.7 72.4 1.0
C23 D:U94201 2.7 70.0 1.0
CE1 D:PHE28 3.8 86.7 1.0
CA H:GLY47 3.9 64.8 1.0
CG1 D:ILE128 4.0 63.8 1.0
O D:PHE46 4.0 56.4 1.0
C26 D:U94201 4.0 73.0 1.0
C22 D:U94201 4.0 69.1 1.0
CG D:PRO48 4.1 64.3 1.0
CD1 D:ILE128 4.1 68.5 1.0
O H:GLY47 4.1 64.4 1.0
O D:GLU26 4.2 71.8 1.0
CA D:GLY27 4.2 74.5 1.0
CD1 D:PHE28 4.4 83.2 1.0
C27 D:U94201 4.5 72.4 1.0
C H:GLY47 4.5 63.0 1.0
CD D:PRO48 4.5 63.0 1.0
CG2 D:ILE128 4.6 59.4 1.0
CZ D:PHE28 4.8 86.7 1.0
O D:GLY27 4.8 75.9 1.0
C D:GLY27 4.8 72.2 1.0
CB D:ILE128 4.9 60.1 1.0

Reference:

H.Huang, D.F.Ceccarelli, S.Orlicky, D.J.St-Cyr, A.Ziemba, P.Garg, S.Plamondon, M.Auer, S.Sidhu, A.Marinier, G.Kleiger, M.Tyers, F.Sicheri. E2 Enzyme Inhibition By Stabilization of A Low-Affinity Interface with Ubiquitin. Nat.Chem.Biol. V. 10 156 2014.
ISSN: ISSN 1552-4450
PubMed: 24316736
DOI: 10.1038/NCHEMBIO.1412
Page generated: Sun Jul 21 19:44:16 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy