Chlorine in PDB 4mj4: Human Iduronidase Apo Structure P21 Form

All present enzymatic activity of Human Iduronidase Apo Structure P21 Form:
3.2.1.76;

The structure of Human Iduronidase Apo Structure P21 Form, PDB code: 4mj4 was solved by H.Bie, J.Yin, X.He, A.R.Kermode, E.D.Goddard-Borger, S.G.Withers, M.N.G.James, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.71 / 2.17
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	63.335, 70.507, 67.303, 90.00, 92.10, 90.00
R / Rfree (%)	20.1 / 24

The binding sites of Chlorine atom in the Human Iduronidase Apo Structure P21 Form (pdb code 4mj4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Iduronidase Apo Structure P21 Form, PDB code: 4mj4:

Chlorine binding site 1 out of 1 in the Human Iduronidase Apo Structure P21 Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Iduronidase Apo Structure P21 Form within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl711 b:28.8 occ:1.00 NH2 A:ARG313 3.3 30.7 1.0 NE A:ARG363 3.3 27.7 1.0 N A:LEU303 3.3 34.4 1.0 NE A:ARG313 3.4 30.0 1.0 O A:LEU303 3.5 33.7 1.0 CG A:ARG363 3.5 27.2 1.0 CD A:PRO302 3.6 33.5 1.0 CH2 A:TRP312 3.7 31.0 1.0 CB A:PRO302 3.7 34.3 1.0 CD A:ARG363 3.8 27.1 1.0 N A:PRO302 3.8 34.5 1.0 CZ A:ARG313 3.8 30.6 1.0 CG A:PRO302 3.9 33.6 1.0 CB A:ASP301 4.0 36.5 1.0 CA A:LEU303 4.1 34.9 1.0 CA A:PRO302 4.1 34.4 1.0 C A:PRO302 4.1 34.9 1.0 CB A:LEU303 4.2 34.8 1.0 O A:HOH867 4.2 31.8 1.0 CZ3 A:TRP312 4.2 30.1 1.0 C A:LEU303 4.2 35.0 1.0 CB A:ARG363 4.4 28.1 1.0 CZ A:ARG363 4.4 28.4 1.0 CE1 A:TYR318 4.4 27.2 1.0 C A:ASP301 4.5 35.1 1.0 NH1 A:ARG363 4.6 29.0 1.0 OH A:TYR318 4.6 27.3 1.0 CD A:ARG313 4.6 30.4 1.0 CA A:ASP301 4.7 35.7 1.0 CZ A:TYR318 4.7 27.2 1.0 CZ2 A:TRP312 4.7 31.7 1.0 CG A:ARG313 4.8 29.9 1.0 CG A:ASP301 5.0 37.0 1.0

H.Bie, J.Yin, X.He, A.R.Kermode, E.D.Goddard-Borger, S.G.Withers, M.N.James. Insights Into Mucopolysaccharidosis I From the Structure and Action of Alpha-L-Iduronidase. Nat.Chem.Biol. V. 9 739 2013.
ISSN: ISSN 1552-4450
PubMed: 24036510
DOI: 10.1038/NCHEMBIO.1357