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Atomistry » Chlorine » PDB 4ms0-4mye » 4mw1 » |
Chlorine in PDB 4mw1: Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444)Enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444)
All present enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444):
6.1.1.10; Protein crystallography data
The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444), PDB code: 4mw1
was solved by
C.Y.Koh,
J.E.Kim,
A.B.Wetzel,
W.J.De Van Der Schueren,
S.Shibata,
J.Liu,
Z.Zhang,
E.Fan,
C.L.M.J.Verlinde,
W.G.J.Hol,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4mw1:
The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444)
(pdb code 4mw1). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444), PDB code: 4mw1: Chlorine binding site 1 out of 1 in 4mw1Go back to Chlorine Binding Sites List in 4mw1
Chlorine binding site 1 out
of 1 in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(3-Chloro-5-Methoxybenzyl)Amino]Propyl}-3-Thiophen-3-Ylurea (Chem 1444)
Mono view Stereo pair view
Reference:
C.Y.Koh,
J.E.Kim,
A.B.Wetzel,
W.J.De Van Der Schueren,
S.Shibata,
R.M.Ranade,
J.Liu,
Z.Zhang,
J.R.Gillespie,
F.S.Buckner,
C.L.Verlinde,
E.Fan,
W.G.Hol.
Structures of Trypanosoma Brucei Methionyl-Trna Synthetase with Urea-Based Inhibitors Provide Guidance For Drug Design Against Sleeping Sickness. Plos Negl Trop Dis V. 8 E2775 2014.
Page generated: Sat Dec 12 10:57:03 2020
ISSN: ISSN 1935-2727 PubMed: 24743796 DOI: 10.1371/JOURNAL.PNTD.0002775 |
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