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Chlorine in PDB 4mya: Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110

Enzymatic activity of Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110

All present enzymatic activity of Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110:
1.1.1.205;

Protein crystallography data

The structure of Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110, PDB code: 4mya was solved by Y.Kim, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak, Csgid, Centerfor Structural Genomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.58 / 1.90
Space group P 4
Cell size a, b, c (Å), α, β, γ (°) 110.852, 110.852, 56.258, 90.00, 90.00, 90.00
R / Rfree (%) 14.7 / 18.4

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110 (pdb code 4mya). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110, PDB code: 4mya:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4mya

Go back to Chlorine Binding Sites List in 4mya
Chlorine binding site 1 out of 2 in the Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:21.8
occ:1.00
CL1 A:2EY501 0.0 21.8 1.0
C19 A:2EY501 1.8 19.2 1.0
C18 A:2EY501 2.7 22.8 1.0
C20 A:2EY501 2.8 17.4 1.0
CD2 A:HIS254 3.8 17.5 1.0
CB A:HIS254 3.9 13.8 1.0
C17 A:2EY501 4.0 24.5 1.0
C21 A:2EY501 4.1 22.0 1.0
CG A:HIS254 4.1 15.9 1.0
C16 A:2EY501 4.6 22.3 1.0
O A:HOH789 4.8 42.0 1.0
NE2 A:HIS254 4.9 12.7 1.0

Chlorine binding site 2 out of 2 in 4mya

Go back to Chlorine Binding Sites List in 4mya
Chlorine binding site 2 out of 2 in the Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl501

b:24.8
occ:1.00
CL1 B:2EY501 0.0 24.8 1.0
C19 B:2EY501 1.8 23.1 1.0
C18 B:2EY501 2.7 24.5 1.0
C20 B:2EY501 2.8 23.3 1.0
O B:HOH802 3.7 43.9 1.0
CD2 B:HIS254 3.8 17.9 1.0
C17 B:2EY501 4.0 23.4 1.0
CB B:HIS254 4.0 14.6 1.0
C21 B:2EY501 4.1 23.9 1.0
CG B:HIS254 4.2 17.8 1.0
C16 B:2EY501 4.6 27.3 1.0
NE2 B:HIS254 4.9 15.2 1.0

Reference:

Y.Kim, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak. Crystal Structure of the Inosine 5'-Monophosphate Dehydrogenase with An Internal Deletion of the Cbs Domain From Bacillus Anthracis Str. Ames Complexed with Inhibitor A110 To Be Published 2013.
Page generated: Sun Jul 21 20:21:07 2024

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