Chlorine in PDB 4myo: Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus

The structure of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus, PDB code: 4myo was solved by P.J.Stogios, G.Minasov, A.Dong, E.Evdokimova, V.Yim, M.Krishnamoorthy, R.Dileo, P.Courvalin, A.Savchenko, W.F.Anderson, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.67 / 2.70
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	91.836, 184.037, 96.909, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 25.4

The structure of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 11;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus (pdb code 4myo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 11 binding sites of Chlorine where determined in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus, PDB code: 4myo:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:57.5 occ:1.00 NZ A:LYS153 3.5 63.5 1.0 N A:PHE168 3.6 46.4 1.0 CB A:PHE168 4.0 46.9 1.0 CA A:LYS167 4.2 46.2 1.0 CG A:LYS167 4.3 68.3 1.0 C A:LYS167 4.4 51.7 1.0 CA A:PHE168 4.4 43.5 1.0 CE A:LYS153 4.6 59.3 1.0 CB A:LYS167 4.7 48.9 1.0 O A:LEU166 4.8 32.2 1.0

Chlorine binding site 2 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:57.4 occ:1.00 CB A:ASN203 3.6 61.8 1.0 NH1 C:ARG88 4.0 41.6 1.0 CG A:ASN203 4.1 71.3 1.0 ND2 A:ASN203 4.2 73.4 1.0 NH2 C:ARG88 4.5 43.5 1.0 CZ C:ARG88 4.7 47.1 1.0 OD1 A:ASN203 4.9 75.7 1.0 CA A:ASN203 5.0 52.5 1.0

Chlorine binding site 3 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl304 b:83.7 occ:1.00 CG A:GLU60 3.5 68.5 1.0 N A:GLU60 3.6 51.8 1.0 OE1 A:GLU60 3.7 82.8 1.0 CD A:GLU60 3.9 75.3 1.0 CA A:TYR59 4.0 48.1 1.0 CB A:GLU60 4.2 69.0 1.0 C A:TYR59 4.3 50.0 1.0 O A:HIS58 4.3 50.8 1.0 CA A:GLU60 4.5 60.2 1.0 CB A:TYR59 4.6 51.7 1.0 CD1 A:TYR59 4.8 65.6 1.0 OE2 A:GLU60 4.9 68.8 1.0

Chlorine binding site 4 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl305 b:70.2 occ:1.00 NZ A:LYS138 3.2 56.8 1.0 N A:ASP118 3.7 47.3 1.0 CA A:GLY117 3.9 47.9 1.0 CE A:LYS138 4.1 55.1 1.0 OD2 A:ASP118 4.3 60.1 1.0 C A:GLY117 4.3 51.0 1.0 OE1 A:GLU120 4.5 62.9 1.0 CG A:ASP118 4.5 54.6 1.0 CB A:ASP118 4.6 45.9 1.0 CA A:ASP118 4.7 40.7 1.0 O A:ASP118 4.7 43.6 1.0 O A:LYS116 4.9 54.3 1.0

Chlorine binding site 5 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:82.5 occ:1.00 NZ B:LYS116 3.8 54.3 1.0 NH1 C:ARG170 3.9 55.8 1.0 NH2 C:ARG170 3.9 65.9 1.0 SD B:MET89 4.2 0.7 1.0 CE B:MET89 4.3 56.7 1.0 CE B:LYS116 4.4 58.5 1.0 CZ C:ARG170 4.4 62.9 1.0

Chlorine binding site 6 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl302 b:56.0 occ:1.00 N B:PHE168 3.6 44.0 1.0 CA B:LYS167 4.2 46.8 1.0 CB B:PHE168 4.2 35.9 1.0 NZ B:LYS153 4.4 58.0 1.0 C B:LYS167 4.4 43.7 1.0 CA B:PHE168 4.5 44.8 1.0 CB B:LYS167 4.5 47.4 1.0 CG B:LYS167 4.8 59.8 1.0 O B:LEU166 4.9 43.9 1.0

Chlorine binding site 7 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl303 b:72.7 occ:1.00 OD2 B:ASP190 3.8 90.3 1.0 N B:MET191 3.9 58.0 1.0 CA B:ASP190 4.2 67.1 1.0 CB B:ASP190 4.4 73.6 1.0 CG B:MET191 4.5 58.2 1.0 CB B:MET191 4.6 52.8 1.0 CG B:ASP190 4.6 85.7 1.0 C B:ASP190 4.6 61.5 1.0 CA B:MET191 4.9 55.7 1.0

Chlorine binding site 8 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl304 b:51.2 occ:1.00 NH2 B:ARG88 3.7 61.0 1.0 CB C:ASN203 3.7 65.9 1.0 ND2 C:ASN203 4.1 63.6 1.0 NH1 B:ARG88 4.4 51.3 1.0 CG C:ASN203 4.4 68.0 1.0 CZ B:ARG88 4.5 56.9 1.0 OD2 B:ASP112 4.7 72.6 1.0 CA C:ASN203 5.0 54.3 1.0

Chlorine binding site 9 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl301 b:69.0 occ:1.00 NH2 C:ARG100 3.0 75.2 1.0 CZ C:ARG100 4.2 69.4 1.0 CG C:GLU104 4.2 54.9 1.0 CB C:GLU104 4.4 53.1 1.0 NE C:ARG100 5.0 63.8 1.0

Chlorine binding site 10 out of 11 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl302 b:66.5 occ:1.00 N C:MET191 3.9 71.4 1.0 CA C:ASP190 4.3 74.6 1.0 CB C:MET191 4.4 63.5 1.0 CB C:ASP190 4.5 82.4 1.0 OD1 C:ASP190 4.5 79.8 1.0 C C:ASP190 4.6 73.4 1.0 CA C:MET191 4.8 57.9 1.0

P.J.Stogios, M.L.Kuhn, E.Evdokimova, P.Courvalin, W.F.Anderson, A.Savchenko. Potential For Reduction of Streptogramin A Resistance Revealed By Structural Analysis of the Vata Acetyltransferase. Antimicrob.Agents Chemother. 2014.
ISSN: ESSN 1098-6596
PubMed: 25223995
DOI: 10.1128/AAC.03743-14