Chlorine in PDB 4n0z: Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1)

Enzymatic activity of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1)

All present enzymatic activity of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1):
1.20.4.1;

Protein crystallography data

The structure of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1), PDB code: 4n0z was solved by M.Yogavel, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	24.20 / 1.70
*Space group*	P 3₂ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	48.400, 48.400, 82.612, 90.00, 90.00, 120.00
*R / R_free (%)*	15.5 / 17.2

Other elements in 4n0z:

The structure of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1) also contains other interesting chemical elements:

Platinum

(Pt)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1) (pdb code 4n0z). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1), PDB code: 4n0z:

Chlorine binding site 1 out of 1 in 4n0z

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Chlorine Binding Sites List in 4n0z

Chlorine binding site 1 out of 1 in the Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1)

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl203 b:31.6 occ:0.26	CL1	A:CPT203	0.0	31.6	0.3
	PT1	A:CPT203	2.3	43.8	0.3
	ND1	A:HIS49	3.0	34.4	1.0
	N1	A:CPT203	3.3	32.7	0.3
	O	A:HOH354	3.6	33.0	1.0
	OD1	A:ASN19	3.6	22.4	1.0
	CG	A:HIS49	3.7	26.2	1.0
	CB	A:HIS49	3.8	21.9	1.0
	CE1	A:HIS49	4.0	35.9	1.0
	O	A:HOH314	4.4	27.5	1.0
	CG	A:ASN19	4.5	23.7	1.0
	CA	A:HIS49	4.5	18.6	1.0
	O	A:MET48	4.6	21.1	0.5
	O	A:HOH333	4.6	32.8	1.0
	O	A:MET48	4.6	21.7	0.5
	ND2	A:ASN19	4.8	20.8	1.0
	O	A:HOH381	4.8	38.3	1.0
	CD2	A:HIS49	4.9	26.8	1.0
	NE2	A:HIS49	4.9	26.4	1.0

Reference:

M.Yogavel, T.Tripathi, S.Rahlfs, K.Becker, A.Sharma. Interaction of Cisplatin with Plasmodium Falciparum Glutaredoxin 1 To Be Published.

Page generated: Wed Oct 28 11:57:25 2020

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