Atomistry » Chlorine » PDB 4my6-4n8z » 4n10
Atomistry »
  Chlorine »
    PDB 4my6-4n8z »
      4n10 »

Chlorine in PDB 4n10: Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

Enzymatic activity of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin:
1.20.4.1;

Protein crystallography data

The structure of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n10 was solved by M.Yogavel, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.35 / 1.87
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 48.652, 48.652, 83.234, 90.00, 90.00, 120.00
R / Rfree (%) 18 / 22.3

Other elements in 4n10:

The structure of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin also contains other interesting chemical elements:

Platinum (Pt) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin (pdb code 4n10). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n10:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 4n10

Go back to Chlorine Binding Sites List in 4n10
Chlorine binding site 1 out of 5 in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:38.3
occ:0.40
 CL1 A:CPT203 0.0 38.3 0.4
PT1 A:CPT203 2.3 36.8 0.4
O A:HOH354 2.7 45.4 1.0
O A:HOH321 2.7 36.9 1.0
SD A:MET59 3.0 35.7 1.0
O A:HOH369 3.5 40.1 1.0
CB A:MET59 3.7 30.9 1.0
CG A:MET59 3.7 41.0 1.0
CE A:MET59 4.5 47.8 1.0
O A:HOH309 4.7 36.5 1.0
CA A:MET59 4.9 26.5 1.0
OE1 A:GLN63 5.0 32.2 0.5
N A:ALA60 5.0 23.4 1.0

Chlorine binding site 2 out of 5 in 4n10

Go back to Chlorine Binding Sites List in 4n10
Chlorine binding site 2 out of 5 in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:44.6
occ:0.54
 CL2 A:CPT204 0.0 44.6 0.5
PT1 A:CPT205 0.5 38.4 0.5
CL2 A:CPT205 2.2 43.5 0.5
CL1 A:CPT205 2.2 40.4 0.5
PT1 A:CPT204 2.3 31.6 0.5
N1 A:CPT205 2.5 36.3 0.5
ND1 A:HIS49 2.9 50.0 1.0
O A:MET48 3.2 29.4 0.5
O A:MET48 3.3 29.4 0.5
O A:HOH347 3.4 36.2 0.9
CL1 A:CPT204 3.5 37.3 0.5
CA A:HIS49 3.5 30.0 1.0
CB A:HIS49 3.6 34.9 1.0
CG A:HIS49 3.7 41.1 1.0
CE1 A:HIS49 4.0 45.1 1.0
C A:MET48 4.1 29.2 0.5
C A:MET48 4.2 29.2 0.5
O A:HOH345 4.3 37.5 0.8
N A:HIS49 4.4 25.7 1.0
N A:VAL50 4.6 24.8 1.0
C A:HIS49 4.6 26.8 1.0
N1 A:CPT204 4.9 35.8 0.5
CD2 A:HIS49 4.9 50.5 1.0

Chlorine binding site 3 out of 5 in 4n10

Go back to Chlorine Binding Sites List in 4n10
Chlorine binding site 3 out of 5 in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:37.3
occ:0.54
 CL1 A:CPT204 0.0 37.3 0.5
N1 A:CPT205 1.2 36.3 0.5
PT1 A:CPT204 2.4 31.6 0.5
O A:HOH336 2.5 42.1 1.0
N1 A:CPT204 3.2 35.8 0.5
PT1 A:CPT205 3.3 38.4 0.5
CL2 A:CPT204 3.5 44.6 0.5
O A:HOH345 3.6 37.5 0.8
CL2 A:CPT205 3.8 43.5 0.5
OD1 A:ASN19 4.3 30.7 1.0
O A:HOH347 4.5 36.2 0.9
ND1 A:HIS49 4.6 50.0 1.0
O A:HOH311 5.0 32.9 1.0

Chlorine binding site 4 out of 5 in 4n10

Go back to Chlorine Binding Sites List in 4n10
Chlorine binding site 4 out of 5 in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl205

b:43.5
occ:0.46
 CL2 A:CPT205 0.0 43.5 0.5
CL2 A:CPT204 2.2 44.6 0.5
PT1 A:CPT205 2.5 38.4 0.5
O A:HOH347 3.0 36.2 0.9
N1 A:CPT205 3.4 36.3 0.5
CL1 A:CPT205 3.5 40.4 0.5
CL1 A:CPT204 3.8 37.3 0.5
PT1 A:CPT204 3.8 31.6 0.5
O A:HOH345 4.4 37.5 0.8
O A:MET48 4.4 29.4 0.5
O A:MET48 4.4 29.4 0.5
ND1 A:HIS49 4.9 50.0 1.0

Chlorine binding site 5 out of 5 in 4n10

Go back to Chlorine Binding Sites List in 4n10
Chlorine binding site 5 out of 5 in the Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Plasmodium Falciparum Oxidized Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl205

b:40.4
occ:0.46
 CL1 A:CPT205 0.0 40.4 0.5
CL2 A:CPT204 2.2 44.6 0.5
PT1 A:CPT205 2.3 38.4 0.5
ND1 A:HIS49 3.0 50.0 1.0
N A:VAL50 3.2 24.8 1.0
CA A:HIS49 3.4 30.0 1.0
CL2 A:CPT205 3.5 43.5 0.5
CG A:HIS49 3.7 41.1 1.0
C A:HIS49 3.8 26.8 1.0
CE1 A:HIS49 3.8 45.1 1.0
PT1 A:CPT204 3.9 31.6 0.5
O A:MET48 3.9 29.4 0.5
O A:MET48 3.9 29.4 0.5
CB A:HIS49 4.0 34.9 1.0
O A:VAL50 4.2 25.9 1.0
CA A:VAL50 4.3 25.9 1.0
N A:HIS49 4.5 25.7 1.0
C A:MET48 4.6 29.2 0.5
C A:MET48 4.6 29.2 0.5
N1 A:CPT205 4.6 36.3 0.5
CB A:VAL50 4.6 24.0 1.0
C A:VAL50 4.7 26.5 1.0
CD2 A:HIS49 4.7 50.5 1.0
NE2 A:HIS49 4.7 46.8 1.0
O A:HOH347 5.0 36.2 0.9
O A:HIS49 5.0 25.5 1.0

Reference:

M.Yogavel, T.Tripathi, S.Rahlfs, K.Becker, A.Sharma. Interaction of Cisplatin with Plasmodium Falciparum Glutaredoxin 1 To Be Published.
Page generated: Wed Oct 28 11:57:26 2020

Last articles

Xe in 6AYK
Xe in 6QII
Xe in 6ASM
Xe in 5NSW
Xe in 6FY9
Xe in 5O1K
Xe in 5O27
Xe in 5M69
Xe in 5KPU
Xe in 5I63
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy