Atomistry » Chlorine » PDB 4myq-4n98 » 4n11
Atomistry »
  Chlorine »
    PDB 4myq-4n98 »
      4n11 »

Chlorine in PDB 4n11: Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

Enzymatic activity of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin:
1.20.4.1;

Protein crystallography data

The structure of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n11 was solved by M.Yogavel, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.46 / 1.97
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 48.478, 48.478, 82.391, 90.00, 90.00, 120.00
R / Rfree (%) 15.7 / 20.8

Other elements in 4n11:

The structure of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin also contains other interesting chemical elements:

Platinum (Pt) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin (pdb code 4n11). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n11:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 4n11

Go back to Chlorine Binding Sites List in 4n11
Chlorine binding site 1 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:29.5
occ:0.40
 CL1 A:CPT204 0.0 29.5 0.4
N1 A:CPT204 0.2 35.3 0.3
PT1 A:CPT204 2.3 39.1 0.3
PT1 A:CPT204 2.3 39.1 0.3
N2 A:CPT204 2.3 33.1 0.3
PT1 A:CPT204 2.3 36.2 0.4
NZ A:LYS26 2.9 50.6 0.5
N1 A:CPT204 3.1 38.6 0.4
N1 A:CPT204 3.3 39.4 0.3
CB A:CYS29 3.3 26.4 1.0
CA A:CYS29 3.5 25.2 1.0
CL1 A:CPT204 3.5 38.3 0.3
CL1 A:CPT204 3.6 31.1 0.3
O A:GLU28 3.6 26.5 1.0
SG A:CYS29 3.7 34.5 1.0
CE A:LYS26 3.8 48.0 0.5
N A:CYS29 4.2 25.8 1.0
N2 A:CPT204 4.2 31.6 0.4
C A:GLU28 4.2 29.3 1.0
CD A:PRO30 4.4 25.6 1.0
O A:THR27 4.5 27.6 1.0
CD A:LYS26 4.5 40.0 0.5
CG A:LYS26 4.6 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CG A:LYS26 4.7 38.5 0.5
CD A:LYS26 4.8 40.0 0.5
N A:PRO30 5.0 21.7 1.0

Chlorine binding site 2 out of 3 in 4n11

Go back to Chlorine Binding Sites List in 4n11
Chlorine binding site 2 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:31.1
occ:0.30
 CL1 A:CPT204 0.0 31.1 0.3
PT1 A:CPT204 2.1 36.2 0.4
PT1 A:CPT204 2.1 39.1 0.3
PT1 A:CPT204 2.1 39.1 0.3
N2 A:CPT204 2.3 31.6 0.4
SG A:CYS29 3.0 34.5 1.0
O A:HOH377 3.1 26.6 0.6
N1 A:CPT204 3.1 39.4 0.3
N1 A:CPT204 3.2 38.6 0.4
N1 A:CPT204 3.6 35.3 0.3
CL1 A:CPT204 3.6 29.5 0.4
CL1 A:CPT204 3.7 38.3 0.3
CD A:PRO30 3.8 25.6 1.0
CD2 A:TYR31 3.8 24.5 1.0
N A:TYR31 4.0 19.7 1.0
N2 A:CPT204 4.0 33.1 0.3
N A:PRO30 4.1 21.7 1.0
CB A:CYS29 4.1 26.4 1.0
CA A:CYS29 4.2 25.2 1.0
C A:CYS29 4.3 22.7 1.0
CB A:TYR31 4.3 18.3 1.0
CG A:TYR31 4.5 22.3 1.0
NZ A:LYS26 4.5 50.6 0.5
CG A:PRO30 4.6 24.4 1.0
CA A:TYR31 4.7 20.4 1.0
CE2 A:TYR31 4.7 29.1 1.0
CB A:PRO30 4.8 23.9 1.0
CA A:PRO30 4.8 22.6 1.0
C A:PRO30 4.9 21.4 1.0
O A:CYS29 5.0 21.9 1.0

Chlorine binding site 3 out of 3 in 4n11

Go back to Chlorine Binding Sites List in 4n11
Chlorine binding site 3 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:38.3
occ:0.30
 CL1 A:CPT204 0.0 38.3 0.3
N1 A:CPT204 0.9 38.6 0.4
N1 A:CPT204 1.0 39.4 0.3
PT1 A:CPT204 2.9 36.2 0.4
PT1 A:CPT204 2.9 39.1 0.3
PT1 A:CPT204 2.9 39.1 0.3
N2 A:CPT204 3.5 33.1 0.3
N2 A:CPT204 3.5 31.6 0.4
CL1 A:CPT204 3.5 29.5 0.4
N1 A:CPT204 3.7 35.3 0.3
CL1 A:CPT204 3.7 31.1 0.3
NZ A:LYS26 3.9 50.6 0.5
CE A:LYS26 4.7 48.0 0.5
O A:HOH377 4.7 26.6 0.6

Reference:

M.Yogavel, T.Tripathi, S.Rahlfs, K.Becker, A.Sharma. Interaction of Cisplatin with Plasmodium Falciparum Glutaredoxin 1 To Be Published.
Page generated: Sun Jul 21 20:25:54 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy