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PDB 4n99-4ngq »
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Chlorine in PDB 4n9a: E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid
Enzymatic activity of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid
All present enzymatic activity of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid, PDB code: 4n9a
was solved by
Z.Yin,
A.J.Oakley,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.46 / 1.90 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 79.780, 67.370, 81.120, 90.00, 113.92, 90.00 |
| R / Rfree (%) | 21.4 / 26.1 |
Other elements in 4n9a:
The structure of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid also contains other interesting chemical elements:
| Calcium | (Ca) | 5 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid
(pdb code 4n9a). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid, PDB code: 4n9a:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid, PDB code: 4n9a:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 4n9a
Go back to
Chlorine Binding Sites List in 4n9a
Chlorine binding site 1 out
of 3 in the E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 4n9a
Go back to
Chlorine Binding Sites List in 4n9a
Chlorine binding site 2 out
of 3 in the E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 4n9a
Go back to
Chlorine Binding Sites List in 4n9a
Chlorine binding site 3 out
of 3 in the E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of E. Coli Sliding Clamp in Complex with (R)-6-Chloro-2,3,4,9-Tetrahydro- 1H-Carbazole-1-Carboxylic Acid within 5.0Å range:
|
Reference:
Z.Yin,
L.R.Whittell,
Y.Wang,
S.Jergic,
M.Liu,
E.J.Harry,
N.E.Dixon,
J.L.Beck,
M.J.Kelso,
A.J.Oakley.
Discovery of Lead Compounds Targeting the Bacterial Sliding Clamp Using A Fragment-Based Approach. J.Med.Chem. V. 57 2799 2014.
ISSN: ISSN 0022-2623
PubMed: 24592885
DOI: 10.1021/JM500122R
Page generated: Sun Jul 21 20:33:44 2024
ISSN: ISSN 0022-2623
PubMed: 24592885
DOI: 10.1021/JM500122R
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