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Chlorine in PDB 4n9j: Crystal Structure of the Cryptic Polo Box Domain of Human PLK4

Enzymatic activity of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4

All present enzymatic activity of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4:
2.7.11.21;

Protein crystallography data

The structure of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4, PDB code: 4n9j was solved by B.Ku, J.H.Kim, K.S.Lee, S.J.Kim, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.11 / 2.60
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 128.063, 128.063, 168.357, 90.00, 90.00, 120.00
R / Rfree (%) 20.2 / 24.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 (pdb code 4n9j). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4, PDB code: 4n9j:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 4n9j

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Chlorine binding site 1 out of 6 in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl901

b:51.4
occ:1.00
 NH2 A:ARG672 3.7 35.0 1.0
NH1 A:ARG672 4.2 24.3 1.0
CZ A:ARG672 4.4 38.5 1.0

Chlorine binding site 2 out of 6 in 4n9j

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Chlorine binding site 2 out of 6 in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl901

b:66.5
occ:1.00
 NZ B:LYS605 2.7 70.8 1.0
NH2 B:ARG603 3.3 48.0 1.0
CD B:LYS605 3.8 73.5 1.0
CE B:LYS605 3.9 70.3 1.0
CZ B:ARG603 4.6 58.1 1.0

Chlorine binding site 3 out of 6 in 4n9j

Go back to Chlorine Binding Sites List in 4n9j
Chlorine binding site 3 out of 6 in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl902

b:90.9
occ:1.00
 NH1 B:ARG598 3.3 46.3 1.0
NH2 B:ARG598 3.4 34.0 1.0
CZ B:ARG598 3.8 35.1 1.0
OE1 B:GLU790 4.0 51.1 1.0
NZ B:LYS702 4.1 38.0 1.0
O B:HOH1046 4.2 36.2 1.0
CE B:LYS702 4.7 35.7 1.0
CD B:GLU790 5.0 53.9 1.0

Chlorine binding site 4 out of 6 in 4n9j

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Chlorine binding site 4 out of 6 in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl903

b:65.1
occ:1.00
 OH B:TYR673 2.6 60.8 1.0
NZ B:LYS681 3.6 38.9 1.0
OH B:TYR682 3.6 46.7 1.0
CZ B:TYR673 3.8 40.6 1.0
OG B:SER671 4.0 48.0 1.0
CB B:SER671 4.2 24.2 1.0
CE2 B:TYR673 4.2 28.4 1.0
CE2 B:TYR682 4.2 40.9 1.0
CZ B:TYR682 4.4 41.5 1.0
CE B:LYS681 4.9 42.2 1.0
CE1 B:TYR673 5.0 32.3 1.0

Chlorine binding site 5 out of 6 in 4n9j

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Chlorine binding site 5 out of 6 in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl904

b:45.0
occ:1.00
 NH2 B:ARG672 3.7 31.2 1.0
NH1 B:ARG672 3.9 26.1 1.0
CZ B:ARG672 4.3 37.7 1.0

Chlorine binding site 6 out of 6 in 4n9j

Go back to Chlorine Binding Sites List in 4n9j
Chlorine binding site 6 out of 6 in the Crystal Structure of the Cryptic Polo Box Domain of Human PLK4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of the Cryptic Polo Box Domain of Human PLK4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl905

b:83.8
occ:1.00
 NE2 B:HIS597 3.3 0.7 1.0
NH2 B:ARG794 3.4 95.8 1.0
CE1 B:HIS597 3.7 0.6 1.0
O B:HOH1043 3.8 50.6 1.0
CZ B:ARG794 3.8 96.0 1.0
NE B:ARG794 4.2 96.5 1.0
CD B:PRO797 4.5 35.3 1.0
CB B:PRO797 4.5 48.8 1.0
NH1 B:ARG794 4.6 93.2 1.0
N B:PRO797 4.6 40.4 1.0
CD2 B:HIS597 4.6 0.0 1.0
CA B:PRO797 4.7 42.4 1.0
CG B:PRO797 4.8 43.0 1.0
ND1 B:HIS597 5.0 0.9 1.0

Reference:

S.Y.Park, J.E.Park, T.S.Kim, J.H.Kim, M.J.Kwak, B.Ku, L.Tian, R.N.Murugan, M.Ahn, S.Komiya, H.Hojo, N.H.Kim, B.Y.Kim, J.K.Bang, R.L.Erikson, K.W.Lee, S.J.Kim, B.H.Oh, W.Yang, K.S.Lee. Molecular Basis For Unidirectional Scaffold Switching of Human PLK4 in Centriole Biogenesis. Nat.Struct.Mol.Biol. V. 21 696 2014.
ISSN: ISSN 1545-9993
PubMed: 24997597
DOI: 10.1038/NSMB.2846
Page generated: Sun Jul 21 20:33:44 2024

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