Chlorine in PDB 4nwe: Lysozyme Under 30 Bar Pressure of Nitrous Oxide

All present enzymatic activity of Lysozyme Under 30 Bar Pressure of Nitrous Oxide:
3.2.1.17;

The structure of Lysozyme Under 30 Bar Pressure of Nitrous Oxide, PDB code: 4nwe was solved by N.Colloc'h, T.Prange, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.58
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	79.188, 79.188, 37.941, 90.00, 90.00, 90.00
R / Rfree (%)	17 / 20

The binding sites of Chlorine atom in the Lysozyme Under 30 Bar Pressure of Nitrous Oxide (pdb code 4nwe). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Lysozyme Under 30 Bar Pressure of Nitrous Oxide, PDB code: 4nwe:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Lysozyme Under 30 Bar Pressure of Nitrous Oxide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lysozyme Under 30 Bar Pressure of Nitrous Oxide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl202 b:28.3 occ:1.00 OH A:TYR23 2.9 15.9 1.0 O A:HOH327 3.6 27.3 1.0 O A:HOH357 3.6 36.8 1.0 CZ A:TYR23 3.6 14.9 1.0 CE1 A:TYR23 3.7 14.3 1.0 CA A:GLY104 4.2 16.6 1.0 O A:ARG21 4.7 21.6 1.0 N A:GLY104 4.8 17.9 1.0 CE2 A:TYR23 4.8 14.5 1.0 CD1 A:TYR23 4.9 15.1 1.0

Chlorine binding site 2 out of 2 in the Lysozyme Under 30 Bar Pressure of Nitrous Oxide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lysozyme Under 30 Bar Pressure of Nitrous Oxide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl203 b:34.3 occ:1.00 OG A:SER24 3.0 22.7 1.0 N A:GLY26 3.1 15.2 1.0 O A:HOH377 3.2 47.4 1.0 CB A:SER24 3.5 19.2 1.0 CA A:GLY26 3.5 14.8 1.0 CA A:GLN121 3.7 25.6 1.0 CD1 A:ILE124 3.8 25.8 1.0 N A:GLN121 4.1 24.5 1.0 N A:LEU25 4.1 17.2 1.0 CB A:GLN121 4.1 30.8 1.0 CG1 A:ILE124 4.2 23.7 1.0 C A:SER24 4.2 17.2 1.0 C A:LEU25 4.3 15.7 1.0 O A:VAL120 4.3 21.8 1.0 CG A:GLN121 4.3 36.2 1.0 CG2 A:VAL120 4.4 23.0 1.0 C A:VAL120 4.4 23.2 1.0 CA A:SER24 4.5 17.6 1.0 C A:GLY26 4.6 14.0 1.0 CA A:LEU25 4.6 16.9 1.0 CD A:GLN121 4.6 41.7 1.0 O A:SER24 4.7 16.6 1.0 N A:ASN27 4.7 13.6 1.0 NE2 A:GLN121 4.7 44.1 1.0 C A:GLN121 4.9 23.9 1.0 CB A:LEU25 4.9 18.3 1.0

J.H.Abraini, G.Marassio, H.N.David, B.Vallone, T.Prange, N.Colloc'h. Crystallographic Studies with Xenon and Nitrous Oxide Provide Evidence For Protein-Dependent Processes in the Mechanisms of General Anesthesia Anesthesiology 2014.
ISSN: ESSN 1528-1175
PubMed: 25211169
DOI: 10.1097/ALN.0000000000000435