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Atomistry » Chlorine » PDB 4nsy-4nzd » 4ny9 » |
Chlorine in PDB 4ny9: Crystal Structure of the Human Pxr-Lbd in Complex with N-{(2R)-1- [(4S)-4-(4-Chlorophenyl)-4-Hydroxy-3,3-Dimethylpiperidin-1-Yl]-3- Methyl-1-Oxobutan-2-Yl}-3-Hydroxy-3-MethylbutanamideProtein crystallography data
The structure of Crystal Structure of the Human Pxr-Lbd in Complex with N-{(2R)-1- [(4S)-4-(4-Chlorophenyl)-4-Hydroxy-3,3-Dimethylpiperidin-1-Yl]-3- Methyl-1-Oxobutan-2-Yl}-3-Hydroxy-3-Methylbutanamide, PDB code: 4ny9
was solved by
J.A.Khan,
D.M.Camac,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Human Pxr-Lbd in Complex with N-{(2R)-1- [(4S)-4-(4-Chlorophenyl)-4-Hydroxy-3,3-Dimethylpiperidin-1-Yl]-3- Methyl-1-Oxobutan-2-Yl}-3-Hydroxy-3-Methylbutanamide
(pdb code 4ny9). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Human Pxr-Lbd in Complex with N-{(2R)-1- [(4S)-4-(4-Chlorophenyl)-4-Hydroxy-3,3-Dimethylpiperidin-1-Yl]-3- Methyl-1-Oxobutan-2-Yl}-3-Hydroxy-3-Methylbutanamide, PDB code: 4ny9: Chlorine binding site 1 out of 1 in 4ny9Go back to Chlorine Binding Sites List in 4ny9
Chlorine binding site 1 out
of 1 in the Crystal Structure of the Human Pxr-Lbd in Complex with N-{(2R)-1- [(4S)-4-(4-Chlorophenyl)-4-Hydroxy-3,3-Dimethylpiperidin-1-Yl]-3- Methyl-1-Oxobutan-2-Yl}-3-Hydroxy-3-Methylbutanamide
Mono view Stereo pair view
Reference:
J.Santella,
J.V.Duncia,
D.Gardner,
H.Wu,
M.T.Dhar,
C.L.Cavallaro,
A.J.Tebben,
P.H.Carter,
J.C.Barrish,
M.Yarde,
S.Briceno,
M.E.Cvijic,
R.Grafstrom,
R.Liu,
S.Patel,
A.Watson,
G.Yang,
A.Rose,
R.Vickery,
J.Caceres Cortes,
C.Caporuscio,
D.Camac,
J.Khan,
Y.An,
W.Foster,
P.Davies,
J.Hynes.
The Discovery of CCR1 Antagonist, Bms-817399, For the Treatment of Rheumatoid Arthritis. J.Med.Chem. 2014.
Page generated: Sat Dec 12 10:59:34 2020
ISSN: ISSN 0022-2623 PubMed: 25101488 DOI: 10.1021/JM5003167 |
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