Chlorine in PDB 4o2w: Crystal Structure of the Third RCC1-Like Domain of HERC1

The structure of Crystal Structure of the Third RCC1-Like Domain of HERC1, PDB code: 4o2w was solved by A.Dong, J.Hu, Y.Li, J.R.Walker, C.Bountra, C.H.Arrowsmith, A.M.Edwards, Y.Tong, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.00
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	53.383, 70.902, 105.549, 70.93, 81.26, 90.84
R / Rfree (%)	18.1 / 22.1

The structure of Crystal Structure of the Third RCC1-Like Domain of HERC1 also contains other interesting chemical elements:

Magnesium

(Mg)

3 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Third RCC1-Like Domain of HERC1 (pdb code 4o2w). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of the Third RCC1-Like Domain of HERC1, PDB code: 4o2w:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Crystal Structure of the Third RCC1-Like Domain of HERC1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Third RCC1-Like Domain of HERC1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl4402 b:34.9 occ:1.00 N A:VAL4080 3.3 13.2 1.0 CA A:PHE4079 3.7 14.1 0.5 CA A:PHE4079 3.8 13.4 0.5 CD1 A:PHE4079 3.9 15.0 0.5 C A:PHE4079 4.0 13.8 0.5 C A:PHE4079 4.1 13.4 0.5 CB A:PHE4079 4.1 14.5 0.5 CB A:THR4098 4.2 13.8 1.0 O A:VAL4080 4.2 12.5 1.0 CB A:VAL4080 4.2 13.0 1.0 CA A:VAL4080 4.3 12.9 1.0 CB A:GLU4099 4.3 21.5 1.0 CB A:PHE4079 4.3 13.6 0.5 N A:GLU4099 4.4 17.1 1.0 CD1 A:PHE4079 4.4 13.9 0.5 CG A:PHE4079 4.5 14.5 0.5 OE1 A:GLU4099 4.5 26.7 1.0 CG2 A:VAL4080 4.6 13.4 1.0 OG1 A:THR4098 4.6 14.1 1.0 C A:VAL4080 4.6 12.7 1.0 O A:GLY4078 4.6 13.2 0.5 O A:GLY4078 4.7 12.1 0.5 N A:SER4100 4.8 20.2 1.0 OG A:SER4100 4.8 25.4 1.0 CG2 A:THR4098 4.8 13.9 1.0 CE1 A:PHE4079 4.9 14.9 0.5 CA A:GLU4099 4.9 19.2 1.0 CG A:PHE4079 4.9 13.5 0.5 N A:PHE4079 4.9 14.1 0.5

Chlorine binding site 2 out of 5 in the Crystal Structure of the Third RCC1-Like Domain of HERC1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Third RCC1-Like Domain of HERC1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl4403 b:37.2 occ:1.00 N A:GLY4240 3.3 23.5 1.0 C A:GLY4238 3.4 26.0 1.0 O A:GLY4238 3.4 26.9 1.0 CA A:SER4206 3.5 18.1 1.0 CB A:SER4206 3.6 18.6 1.0 CA A:GLY4240 3.7 22.0 1.0 CA A:GLY4238 3.7 24.8 1.0 N A:ILE4239 4.0 25.6 1.0 O A:HOH4531 4.0 18.6 1.0 C A:ILE4239 4.1 24.4 1.0 N A:SER4206 4.2 17.9 1.0 O A:GLY4205 4.3 18.1 1.0 N A:GLY4238 4.3 24.5 1.0 C A:GLY4205 4.5 18.5 1.0 CA A:ILE4239 4.5 25.0 1.0 C A:SER4206 4.7 17.3 1.0 O A:SER4206 4.7 16.9 1.0 O A:ASP4204 4.9 17.9 1.0 OG A:SER4206 5.0 19.1 1.0 O A:ILE4239 5.0 26.5 1.0

Chlorine binding site 3 out of 5 in the Crystal Structure of the Third RCC1-Like Domain of HERC1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Third RCC1-Like Domain of HERC1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl4404 b:15.7 occ:1.00 NH1 A:ARG4179 3.1 14.0 1.0 N D:SER4064 3.2 13.3 1.0 NZ A:LYS4154 3.5 15.8 1.0 CD A:ARG4179 3.7 13.4 1.0 CB D:SER4064 3.8 13.7 1.0 CZ A:PHE4156 3.8 13.9 1.0 CA D:SER4064 3.9 13.7 1.0 CZ A:ARG4179 4.0 13.6 1.0 CE A:LYS4154 4.0 15.0 1.0 CD A:LYS4154 4.1 14.5 1.0 CB D:ASN4063 4.1 15.5 1.0 C D:ASN4063 4.1 14.1 1.0 NE A:ARG4179 4.2 13.6 1.0 CA D:ASN4063 4.2 14.8 1.0 CE2 A:PHE4156 4.3 13.9 1.0 OE2 A:GLU4134 4.3 24.6 1.0 OG D:SER4064 4.4 13.6 1.0 OD1 D:ASP4065 4.4 16.2 1.0 C D:SER4064 4.4 13.7 1.0 N D:ASP4065 4.6 13.6 1.0 CG A:ARG4179 4.7 13.3 1.0 CB A:ARG4179 4.7 13.1 1.0 CE1 A:PHE4156 4.9 14.2 1.0 O A:HOH4554 4.9 11.9 1.0

Chlorine binding site 4 out of 5 in the Crystal Structure of the Third RCC1-Like Domain of HERC1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Third RCC1-Like Domain of HERC1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl4402 b:35.6 occ:1.00 N D:GLY4240 3.4 23.5 1.0 CB D:SER4206 3.5 18.2 1.0 CA D:SER4206 3.6 17.3 1.0 C D:GLY4238 3.7 25.8 1.0 CA D:GLY4240 3.7 22.5 1.0 CA D:GLY4238 3.9 25.9 1.0 O D:GLY4238 4.0 28.1 1.0 N D:ILE4239 4.0 26.0 1.0 O D:HOH4508 4.1 16.3 1.0 C D:ILE4239 4.2 25.0 1.0 N D:SER4206 4.3 17.1 1.0 O D:GLY4205 4.3 18.4 1.0 C D:GLY4205 4.5 17.2 1.0 N D:GLY4238 4.5 25.2 1.0 CA D:ILE4239 4.6 25.5 1.0 C D:SER4206 4.8 17.4 1.0 OG D:SER4206 4.9 18.2 1.0 O D:SER4206 4.9 17.3 1.0 O D:ASP4204 4.9 16.6 1.0

Chlorine binding site 5 out of 5 in the Crystal Structure of the Third RCC1-Like Domain of HERC1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of the Third RCC1-Like Domain of HERC1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl4403 b:28.2 occ:1.00 ND1 D:HIS4007 3.0 15.6 1.0 NE2 D:GLN4009 3.0 13.9 1.0 N D:ARG4006 3.3 16.9 1.0 N D:HIS4007 3.6 15.7 1.0 CB D:ARG4006 3.7 20.5 1.0 CE1 D:HIS4007 3.7 15.7 1.0 OD1 D:ASN4037 3.8 16.4 1.0 OE1 D:GLN4009 3.8 13.4 1.0 CD D:GLN4009 3.8 14.1 1.0 CA D:ARG4006 3.8 17.9 1.0 CG D:ASN4037 3.9 15.8 1.0 CG D:HIS4007 4.1 15.3 1.0 C D:ARG4006 4.1 17.0 1.0 CB D:ALA4004 4.1 16.9 1.0 N D:GLY4005 4.1 16.0 1.0 C D:GLY4005 4.2 16.3 1.0 ND2 D:ASN4037 4.3 16.8 1.0 CB D:HIS4007 4.4 15.0 1.0 CB D:ASN4037 4.4 15.0 1.0 CA D:GLY4005 4.4 16.5 1.0 CG D:ARG4006 4.4 23.4 1.0 C D:ALA4004 4.5 16.4 1.0 O D:HOH4610 4.5 36.7 1.0 CA D:HIS4007 4.6 14.9 1.0 CA D:ALA4004 4.9 16.8 1.0 NE2 D:HIS4007 4.9 16.1 1.0 O D:ALA4004 5.0 15.8 1.0

J.Hu, A.Dong, Y.Li, J.R.Walker, C.Bountra, C.H.Arrowsmith, A.M.Edwards, Y.Tong, Structural Genomics Consortium (Sgc). Crystal Structure of the Third RCC1-Like Domain of HERC1 To Be Published.