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Chlorine in PDB 4oas: Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Protein crystallography data
The structure of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25, PDB code: 4oas
was solved by
X.Huang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 1.70 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.554, 99.035, 107.076, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.4 / 23.9 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
(pdb code 4oas). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25, PDB code: 4oas:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Chlorine where determined in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25, PDB code: 4oas:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
Chlorine binding site 1 out of 6 in 4oas
Go back to
Chlorine Binding Sites List in 4oas
Chlorine binding site 1 out
of 6 in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25 within 5.0Å range:
|
Chlorine binding site 2 out of 6 in 4oas
Go back to
Chlorine Binding Sites List in 4oas
Chlorine binding site 2 out
of 6 in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25 within 5.0Å range:
|
Chlorine binding site 3 out of 6 in 4oas
Go back to
Chlorine Binding Sites List in 4oas
Chlorine binding site 3 out
of 6 in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25 within 5.0Å range:
|
Chlorine binding site 4 out of 6 in 4oas
Go back to
Chlorine Binding Sites List in 4oas
Chlorine binding site 4 out
of 6 in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25 within 5.0Å range:
|
Chlorine binding site 5 out of 6 in 4oas
Go back to
Chlorine Binding Sites List in 4oas
Chlorine binding site 5 out
of 6 in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25 within 5.0Å range:
|
Chlorine binding site 6 out of 6 in 4oas
Go back to
Chlorine Binding Sites List in 4oas
Chlorine binding site 6 out
of 6 in the Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Co-Crystal Structure of MDM2 (17-111) in Complex with Compound 25 within 5.0Å range:
|
Reference:
D.Sun,
Z.Li,
Y.Rew,
M.Gribble,
M.D.Bartberger,
H.P.Beck,
J.Canon,
A.Chen,
X.Chen,
D.Chow,
J.Deignan,
J.Duquette,
J.Eksterowicz,
B.Fisher,
B.M.Fox,
J.Fu,
A.Z.Gonzalez,
F.Gonzalez-Lopez De Turiso,
J.B.Houze,
X.Huang,
M.Jiang,
L.Jin,
F.Kayser,
J.J.Liu,
M.C.Lo,
A.M.Long,
B.Lucas,
L.R.Mcgee,
J.Mcintosh,
J.Mihalic,
J.D.Oliner,
T.Osgood,
M.L.Peterson,
P.Roveto,
A.Y.Saiki,
P.Shaffer,
M.Toteva,
Y.Wang,
Y.C.Wang,
S.Wortman,
P.Yakowec,
X.Yan,
Q.Ye,
D.Yu,
M.Yu,
X.Zhao,
J.Zhou,
J.Zhu,
S.H.Olson,
J.C.Medina.
Discovery of Amg 232, A Potent, Selective, and Orally Bioavailable MDM2-P53 Inhibitor in Clinical Development. J.Med.Chem. V. 57 1454 2014.
ISSN: ISSN 0022-2623
PubMed: 24456472
DOI: 10.1021/JM401753E
Page generated: Thu Jul 25 23:20:19 2024
ISSN: ISSN 0022-2623
PubMed: 24456472
DOI: 10.1021/JM401753E
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