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Chlorine in PDB 4obc: Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238)

Enzymatic activity of Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238)

All present enzymatic activity of Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238):
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238), PDB code: 4obc was solved by T.E.Edwards, J.Abendroth, T.C.Appleby, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 140.208, 140.208, 92.567, 90.00, 90.00, 120.00
R / Rfree (%) 18.8 / 22.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238) (pdb code 4obc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238), PDB code: 4obc:

Chlorine binding site 1 out of 1 in 4obc

Go back to Chlorine Binding Sites List in 4obc
Chlorine binding site 1 out of 1 in the Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Hcv Polymerase NS5B Genotype 2A Jfh-1 Isolate with the S15G, C223H, V321I Resistance Mutations Against the Guanosine Analog Gs-0938 (Psi-3529238) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl605

b:74.3
occ:1.00
 N A:SER403 3.5 36.5 1.0
ND1 A:HIS402 3.7 40.5 1.0
O A:SER403 3.9 34.7 1.0
CA A:HIS402 4.0 38.4 1.0
O A:ARG401 4.2 39.6 1.0
CE1 A:HIS402 4.2 38.6 1.0
C A:HIS402 4.3 37.7 1.0
CB A:SER403 4.3 35.2 1.0
CA A:SER403 4.3 35.5 1.0
CG A:HIS402 4.4 39.1 1.0
ND2 A:ASN406 4.6 39.7 1.0
C A:SER403 4.6 34.8 1.0
CB A:HIS402 4.7 37.5 1.0

Reference:

A.M.Lam, T.E.Edwards, R.T.Mosley, E.Murakami, S.Bansal, C.Lugo, H.Bao, M.J.Otto, M.J.Sofia, P.A.Furman. Molecular and Structural Basis For the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance. Antimicrob.Agents Chemother. V. 58 6861 2014.
ISSN: ISSN 0066-4804
PubMed: 25182647
DOI: 10.1128/AAC.03847-14
Page generated: Sat Dec 12 11:00:38 2020

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