Chlorine in PDB 4os4: Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1)

Enzymatic activity of Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1)

All present enzymatic activity of Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1):
3.4.21.73;

Protein crystallography data

The structure of Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1), PDB code: 4os4 was solved by S.Chen, F.Pojer, C.Heinis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.60 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 52.427, 53.874, 82.988, 90.00, 90.00, 90.00
R / Rfree (%) 16.4 / 21.4

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1) (pdb code 4os4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1), PDB code: 4os4:

Chlorine binding site 1 out of 1 in 4os4

Go back to Chlorine Binding Sites List in 4os4
Chlorine binding site 1 out of 1 in the Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Urokinase-Type Plasminogen Activator (Upa) Complexed with Bicyclic Peptide UK603 (Bicyclic 1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl305

b:50.9
occ:1.00
 CD1 A:TYR127 3.6 47.8 1.0
NH2 A:ARG230 3.6 23.8 1.0
NH1 A:ARG230 3.7 24.2 1.0
ND1 A:HIS233 3.7 27.9 1.0
CE1 A:TYR127 3.8 48.3 1.0
O A:HOH574 3.9 29.5 1.0
CZ A:ARG230 4.1 23.8 1.0
CA A:HIS233 4.2 21.9 1.0
CB A:HIS233 4.3 24.2 1.0
CG A:HIS233 4.4 26.7 1.0
CE1 A:HIS233 4.7 28.6 1.0
CG A:TYR127 4.8 47.4 1.0
O A:SER232 4.9 20.9 1.0
N A:HIS233 4.9 20.0 1.0

Reference:

S.Chen, R.Gopalakrishnan, T.Schaer, F.Marger, R.Hovius, D.Bertrand, F.Pojer, C.Heinis. Dithiol Amino Acids Can Structurally Shape and Enhance the Ligand-Binding Properties of Polypeptides. Nat Chem V. 6 1009 2014.
ISSN: ISSN 1755-4349
PubMed: 25343607
DOI: 10.1038/NCHEM.2043
Page generated: Sat Dec 12 11:01:33 2020

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