Chlorine in PDB 4oyk: Structure of Hoip Pub Domain Bound to Otulin Pim

All present enzymatic activity of Structure of Hoip Pub Domain Bound to Otulin Pim:
3.4.19.12;

The structure of Structure of Hoip Pub Domain Bound to Otulin Pim, PDB code: 4oyk was solved by P.R.Elliott, D.Komander, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.47 / 2.00
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	64.049, 64.049, 172.022, 90.00, 90.00, 120.00
R / Rfree (%)	20.1 / 23.7

The binding sites of Chlorine atom in the Structure of Hoip Pub Domain Bound to Otulin Pim (pdb code 4oyk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structure of Hoip Pub Domain Bound to Otulin Pim, PDB code: 4oyk:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Structure of Hoip Pub Domain Bound to Otulin Pim


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Hoip Pub Domain Bound to Otulin Pim within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:29.4 occ:1.00 O A:HOH426 2.8 34.0 1.0 O A:HOH386 3.0 39.9 1.0 N A:PHE29 3.3 21.8 1.0 NH2 A:ARG84 3.4 19.9 1.0 CA A:ALA28 3.9 29.6 1.0 C A:ALA28 4.1 25.3 1.0 OE2 A:GLU80 4.2 24.4 1.0 O A:PHE29 4.2 25.2 1.0 CA A:PHE29 4.3 22.7 1.0 CD2 A:PHE29 4.3 26.0 1.0 CB A:PHE29 4.3 23.9 1.0 O A:GLN27 4.3 26.9 1.0 CD1 A:LEU154 4.4 22.9 1.0 CB A:ALA28 4.5 33.3 1.0 CZ A:ARG84 4.6 20.6 1.0 CD2 A:LEU154 4.6 19.9 1.0 NH1 A:ARG157 4.7 40.2 1.0 C A:PHE29 4.7 28.1 1.0 CG A:PHE29 4.8 26.1 1.0 CG A:LEU154 4.9 21.4 1.0 CB A:LEU154 4.9 24.4 1.0 NH2 A:ARG157 4.9 45.1 1.0 N A:ALA28 5.0 36.3 1.0

Chlorine binding site 2 out of 3 in the Structure of Hoip Pub Domain Bound to Otulin Pim


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Hoip Pub Domain Bound to Otulin Pim within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl201 b:37.4 occ:1.00 N B:PHE29 3.1 28.7 1.0 O B:HOH402 3.4 32.5 1.0 NH2 B:ARG84 3.5 16.6 1.0 CA B:ALA28 3.9 39.2 1.0 O B:PHE29 3.9 32.5 1.0 CB B:PHE29 4.0 30.8 1.0 C B:ALA28 4.0 37.8 1.0 CA B:PHE29 4.0 30.8 1.0 CD2 B:PHE29 4.1 31.6 1.0 OE2 B:GLU80 4.2 28.4 1.0 CD1 B:LEU154 4.3 23.3 1.0 O B:GLN27 4.4 34.0 1.0 C B:PHE29 4.4 38.4 1.0 CG B:PHE29 4.5 38.7 1.0 CD2 B:LEU154 4.5 22.2 1.0 CB B:ALA28 4.5 46.2 1.0 CZ B:ARG84 4.7 21.8 1.0 CG B:LEU154 4.9 16.9 1.0

Chlorine binding site 3 out of 3 in the Structure of Hoip Pub Domain Bound to Otulin Pim


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Hoip Pub Domain Bound to Otulin Pim within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl202 b:43.7 occ:1.00 NE B:ARG58 2.9 41.1 1.0 NH2 B:ARG58 3.2 38.6 1.0 CZ B:ARG58 3.5 45.0 1.0 CB B:ARG58 4.0 19.8 1.0 CG B:ARG58 4.0 27.2 1.0 CD B:ARG58 4.0 36.9 1.0 NH1 B:ARG58 4.8 50.1 1.0

P.R.Elliott, S.V.Nielsen, P.Marco-Casanova, B.K.Fiil, K.Keusekotten, N.Mailand, S.M.Freund, M.Gyrd-Hansen, D.Komander. Molecular Basis and Regulation of Otulin-Lubac Interaction. Mol.Cell V. 54 335 2014.
ISSN: ISSN 1097-4164
PubMed: 24726323
DOI: 10.1016/J.MOLCEL.2014.03.018