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Atomistry » Chlorine » PDB 4pjz-4pw0 » 4pmt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4pjz-4pw0 » 4pmt » |
Chlorine in PDB 4pmt: The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- DiamineEnzymatic activity of The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- Diamine
All present enzymatic activity of The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- Diamine:
2.7.10.1; Protein crystallography data
The structure of The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- Diamine, PDB code: 4pmt
was solved by
H.P.Su,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- Diamine
(pdb code 4pmt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- Diamine, PDB code: 4pmt: Chlorine binding site 1 out of 1 in 4pmtGo back to Chlorine Binding Sites List in 4pmt
Chlorine binding site 1 out
of 1 in the The Structure of Trka Kinase Bound to the Inhibitor N~4~-(4-Morpholin- 4-Ylphenyl)-N~6~-(Pyridin-3-Ylmethyl)Pyrido[3,2-D]Pyrimidine-4,6- Diamine
Mono view Stereo pair view
Reference:
S.J.Stachel,
J.M.Sanders,
D.A.Henze,
M.T.Rudd,
H.P.Su,
Y.Li,
K.K.Nanda,
M.S.Egbertson,
P.J.Manley,
K.L.Jones,
E.J.Brnardic,
A.Green,
J.A.Grobler,
B.Hanney,
M.Leitl,
M.T.Lai,
V.Munshi,
D.Murphy,
K.Rickert,
D.Riley,
A.Krasowska-Zoladek,
C.Daley,
P.Zuck,
S.A.Kane,
M.T.Bilodeau.
Maximizing Diversity From A Kinase Screen: Identification of Novel and Selective Pan-Trk Inhibitors For Chronic Pain. J.Med.Chem. V. 57 5800 2014.
Page generated: Sat Dec 12 11:03:43 2020
ISSN: ISSN 0022-2623 PubMed: 24914455 DOI: 10.1021/JM5006429 |
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