Chlorine in PDB 4qoc: Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid

The structure of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid, PDB code: 4qoc was solved by X.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.576, 98.925, 103.921, 90.00, 90.00, 90.00
R / Rfree (%)	23.8 / 25.3

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>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid (pdb code 4qoc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 12 binding sites of Chlorine where determined in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid, PDB code: 4qoc:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:22.2 occ:1.00 CL2 A:35T201 0.0 22.2 1.0 C16 A:35T201 1.7 19.4 1.0 C17 A:35T201 2.7 18.9 1.0 C15 A:35T201 2.7 19.1 1.0 CB A:HIS96 3.5 17.4 1.0 CG A:HIS96 3.5 18.1 1.0 CE2 A:TYR100 3.6 21.4 1.0 CD1 A:LEU54 3.7 19.4 1.0 CA A:HIS96 3.7 17.0 1.0 CG2 A:ILE99 3.8 14.3 1.0 O A:HIS96 3.8 15.3 1.0 CD2 A:TYR100 3.9 20.1 1.0 CD2 A:HIS96 3.9 18.3 1.0 CB A:ILE99 4.0 14.3 1.0 ND1 A:HIS96 4.0 20.2 1.0 C6 A:35T201 4.0 18.4 1.0 C14 A:35T201 4.1 20.0 1.0 CD1 A:ILE99 4.1 16.0 1.0 C A:HIS96 4.2 16.2 1.0 CZ A:TYR100 4.3 21.2 1.0 NE2 A:HIS96 4.5 20.3 1.0 C13 A:35T201 4.6 19.2 1.0 CE1 A:HIS96 4.6 19.6 1.0 CG1 A:ILE99 4.6 14.4 1.0 OH A:TYR100 4.7 25.6 1.0 CG A:LEU54 4.8 17.2 1.0 CG A:TYR100 4.9 17.5 1.0 N A:HIS96 5.0 18.6 1.0

Chlorine binding site 2 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:22.6 occ:1.00 CL1 A:35T201 0.0 22.6 1.0 C10 A:35T201 1.7 16.7 1.0 C11 A:35T201 2.6 17.2 1.0 C9 A:35T201 2.7 17.4 1.0 CD1 A:ILE61 3.7 12.5 1.0 CG2 A:ILE99 3.8 14.3 1.0 C12 A:35T201 4.0 17.3 1.0 C8 A:35T201 4.0 16.7 1.0 CB A:LEU57 4.0 13.7 1.0 CD1 A:LEU57 4.2 18.1 1.0 CE2 A:PHE86 4.2 17.3 1.0 CZ A:PHE86 4.3 18.6 1.0 C7 A:35T201 4.4 17.6 1.0 CD1 A:ILE103 4.6 15.7 1.0 CZ A:PHE91 4.6 15.1 1.0 CG A:LEU57 4.6 15.2 1.0 CE1 A:PHE91 4.6 16.6 1.0 CD1 A:LEU54 4.8 19.4 1.0 C A:LEU57 4.9 13.2 1.0 CD1 A:ILE99 4.9 16.0 1.0 CD2 A:LEU57 4.9 18.2 1.0 N A:GLY58 5.0 11.3 1.0

Chlorine binding site 3 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl201 b:23.2 occ:1.00 CL2 C:35T201 0.0 23.2 1.0 C16 C:35T201 1.7 20.8 1.0 C17 C:35T201 2.6 19.7 1.0 C15 C:35T201 2.7 20.0 1.0 CB C:HIS96 3.4 18.9 1.0 CG C:HIS96 3.5 20.2 1.0 CG2 C:ILE99 3.6 14.6 1.0 CE1 C:TYR100 3.6 22.5 1.0 O C:HIS96 3.7 14.5 1.0 CA C:HIS96 3.7 17.6 1.0 CD1 C:LEU54 3.7 15.8 1.0 CB C:ILE99 3.8 14.8 1.0 ND1 C:HIS96 3.8 19.5 1.0 CD1 C:TYR100 3.9 20.8 1.0 C6 C:35T201 4.0 18.5 1.0 C14 C:35T201 4.0 20.0 1.0 CD1 C:ILE99 4.0 17.9 1.0 CD2 C:HIS96 4.1 20.8 1.0 C C:HIS96 4.2 17.4 1.0 C13 C:35T201 4.5 18.7 1.0 CE1 C:HIS96 4.5 20.2 1.0 CG1 C:ILE99 4.5 15.4 1.0 CZ C:TYR100 4.5 22.0 1.0 CG C:LEU54 4.6 14.3 1.0 CD1 C:ILE19 4.6 31.1 1.0 NE2 C:HIS96 4.6 20.1 1.0 CG C:TYR100 4.9 19.3 1.0 N C:HIS96 4.9 18.4 1.0 N C:TYR100 4.9 15.8 1.0

Chlorine binding site 4 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl201 b:25.8 occ:1.00 CL1 C:35T201 0.0 25.8 1.0 C10 C:35T201 1.7 20.5 1.0 C9 C:35T201 2.6 19.8 1.0 C11 C:35T201 2.7 20.0 1.0 CD1 C:ILE61 3.7 14.2 1.0 C8 C:35T201 3.9 18.9 1.0 CG2 C:ILE99 4.0 14.6 1.0 CB C:LEU57 4.0 14.4 1.0 C12 C:35T201 4.0 19.4 1.0 CE2 C:PHE86 4.1 20.6 1.0 CZ C:PHE86 4.1 21.3 1.0 CZ C:PHE91 4.2 18.1 1.0 CD1 C:LEU57 4.2 16.2 1.0 CE1 C:PHE91 4.3 17.1 1.0 C7 C:35T201 4.4 19.4 1.0 CD1 C:LEU54 4.6 15.8 1.0 CD1 C:ILE99 4.6 17.9 1.0 CG C:LEU57 4.7 17.4 1.0 CD1 C:ILE103 4.8 17.6 1.0 C C:LEU57 5.0 13.0 1.0

Chlorine binding site 5 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl201 b:26.5 occ:1.00 CL2 E:35T201 0.0 26.5 1.0 C16 E:35T201 1.7 24.8 1.0 C17 E:35T201 2.7 23.9 1.0 C15 E:35T201 2.7 25.1 1.0 CE2 E:TYR100 3.5 22.8 1.0 CG E:HIS96 3.6 22.9 1.0 CG2 E:ILE99 3.6 18.4 1.0 CB E:HIS96 3.6 22.1 1.0 O E:HIS96 3.7 20.2 1.0 CA E:HIS96 3.8 22.4 1.0 CB E:ILE99 3.8 18.2 1.0 CD2 E:HIS96 3.9 22.4 1.0 CZ E:TYR100 3.9 22.6 1.0 CD2 E:TYR100 3.9 21.2 1.0 ND1 E:HIS96 4.0 24.0 1.0 C6 E:35T201 4.0 22.9 1.0 C14 E:35T201 4.0 24.8 1.0 CD2 E:LEU54 4.0 19.2 1.0 CD1 E:ILE99 4.2 17.2 1.0 C E:HIS96 4.2 22.3 1.0 OH E:TYR100 4.3 25.5 1.0 NE2 E:HIS96 4.4 23.9 1.0 CE1 E:HIS96 4.4 24.7 1.0 C13 E:35T201 4.5 24.2 1.0 CE1 E:TYR100 4.6 23.3 1.0 CG E:TYR100 4.6 19.4 1.0 CG1 E:ILE99 4.6 18.2 1.0 CD1 E:TYR100 4.9 20.6 1.0 N E:TYR100 4.9 16.9 1.0 O E:HOH346 4.9 39.8 1.0 CD1 E:LEU54 5.0 20.4 1.0 CD1 E:ILE19 5.0 38.4 1.0

Chlorine binding site 6 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl201 b:27.2 occ:1.00 CL1 E:35T201 0.0 27.2 1.0 C10 E:35T201 1.7 21.2 1.0 C11 E:35T201 2.7 20.0 1.0 C9 E:35T201 2.7 20.9 1.0 CD1 E:LEU57 3.7 22.8 1.0 CG2 E:ILE99 3.9 18.4 1.0 CD1 E:ILE61 3.9 17.0 1.0 CE2 E:PHE86 4.0 22.3 1.0 CZ E:PHE86 4.0 21.8 1.0 C8 E:35T201 4.0 19.8 1.0 C12 E:35T201 4.1 20.6 1.0 CB E:LEU57 4.1 17.2 1.0 CG E:LEU57 4.3 20.8 1.0 CZ E:PHE91 4.4 19.3 1.0 C7 E:35T201 4.5 19.8 1.0 CD2 E:LEU57 4.6 22.5 1.0 CE1 E:PHE91 4.6 18.2 1.0 CD1 E:ILE103 4.6 19.9 1.0

Chlorine binding site 7 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl201 b:24.8 occ:1.00 CL2 G:35T201 0.0 24.8 1.0 C16 G:35T201 1.7 26.7 1.0 C17 G:35T201 2.7 27.5 1.0 C15 G:35T201 2.8 27.2 1.0 CB G:HIS96 3.4 24.4 1.0 CG G:HIS96 3.5 25.7 1.0 CA G:HIS96 3.5 24.6 1.0 O G:HIS96 3.6 23.0 1.0 CG2 G:ILE99 3.6 16.4 1.0 CB G:ILE99 3.7 18.3 1.0 CE2 G:TYR100 3.7 18.9 1.0 CD2 G:HIS96 3.9 25.9 1.0 C G:HIS96 4.0 23.8 1.0 CD2 G:TYR100 4.0 18.8 1.0 ND1 G:HIS96 4.0 25.5 1.0 C6 G:35T201 4.1 29.0 1.0 CD1 G:ILE99 4.1 20.6 1.0 C14 G:35T201 4.2 28.5 1.0 CZ G:TYR100 4.3 21.4 1.0 CG1 G:ILE99 4.5 18.3 1.0 CD2 G:LEU54 4.5 22.1 1.0 NE2 G:HIS96 4.5 24.9 1.0 CE1 G:HIS96 4.6 26.2 1.0 C13 G:35T201 4.6 28.1 1.0 OH G:TYR100 4.7 23.2 1.0 CG G:TYR100 4.7 17.6 1.0 N G:HIS96 4.7 26.8 1.0 N G:TYR100 4.7 16.9 1.0 O G:HOH324 4.8 38.7 1.0 CA G:ILE99 4.9 18.0 1.0 CE1 G:TYR100 5.0 21.0 1.0

Chlorine binding site 8 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl201 b:30.6 occ:1.00 CL1 G:35T201 0.0 30.6 1.0 C10 G:35T201 1.7 27.2 1.0 C9 G:35T201 2.6 28.1 1.0 C11 G:35T201 2.8 27.2 1.0 CD1 G:ILE61 3.6 34.4 1.0 C8 G:35T201 4.0 28.0 1.0 CE2 G:PHE86 4.1 27.3 1.0 CG2 G:ILE99 4.1 16.4 1.0 C12 G:35T201 4.1 27.4 1.0 CB G:LEU57 4.1 22.6 1.0 CD1 G:LEU57 4.2 24.5 1.0 CZ G:PHE86 4.2 26.8 1.0 CZ G:PHE91 4.2 27.1 1.0 CE1 G:PHE91 4.4 27.2 1.0 C7 G:35T201 4.5 28.1 1.0 CG G:LEU57 4.8 22.2 1.0 CG1 G:ILE61 4.9 36.3 1.0 CD1 G:ILE99 5.0 20.6 1.0

Chlorine binding site 9 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ I:Cl201 b:23.2 occ:1.00 CL2 I:35T201 0.0 23.2 1.0 C16 I:35T201 1.7 21.0 1.0 C15 I:35T201 2.7 21.4 1.0 C17 I:35T201 2.7 19.8 1.0 CG I:HIS96 3.5 23.2 1.0 CG2 I:ILE99 3.7 19.2 1.0 CB I:HIS96 3.7 22.4 1.0 CA I:HIS96 3.7 22.8 1.0 CE1 I:TYR100 3.7 19.1 1.0 CD1 I:TYR100 3.7 18.4 1.0 O I:HIS96 3.7 22.3 1.0 CB I:ILE99 3.8 19.0 1.0 CD2 I:HIS96 3.8 23.4 1.0 ND1 I:HIS96 3.9 24.2 1.0 CD1 I:ILE99 4.0 18.4 1.0 CD1 I:LEU54 4.0 16.4 1.0 C14 I:35T201 4.0 21.2 1.0 C6 I:35T201 4.1 19.2 1.0 C I:HIS96 4.2 22.6 1.0 CG I:LEU54 4.3 17.1 1.0 NE2 I:HIS96 4.4 24.4 1.0 CE1 I:HIS96 4.4 24.7 1.0 CG1 I:ILE99 4.4 18.0 1.0 C13 I:35T201 4.5 19.9 1.0 O I:HOH354 4.6 50.9 1.0 N I:HIS96 4.9 22.1 1.0 N I:TYR100 4.9 17.1 1.0

Chlorine binding site 10 out of 12 in the Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of Compound 16 Bound to MDM2(17-111), {(3R,5R,6S)-5- (3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(1S)-1-Cyclopropyl-2- (Pyrrolidin-1-Ylsulfonyl)Ethyl]-3-Methyl-2-Oxopiperidin-3-Yl}Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ I:Cl201 b:25.6 occ:1.00 CL1 I:35T201 0.0 25.6 1.0 C10 I:35T201 1.7 19.6 1.0 C11 I:35T201 2.7 18.2 1.0 C9 I:35T201 2.7 18.2 1.0 CD1 I:ILE61 3.7 11.3 1.0 CG2 I:ILE99 3.8 19.2 1.0 C12 I:35T201 4.0 17.3 1.0 C8 I:35T201 4.0 17.3 1.0 CD1 I:LEU57 4.0 20.7 1.0 CB I:LEU57 4.1 15.9 1.0 CD1 I:LEU54 4.1 16.4 1.0 CE2 I:PHE86 4.2 23.9 1.0 CZ I:PHE91 4.2 17.8 1.0 CE1 I:PHE91 4.3 18.7 1.0 CZ I:PHE86 4.3 22.6 1.0 C7 I:35T201 4.4 17.7 1.0 CG I:LEU57 4.6 19.1 1.0 CD1 I:ILE103 4.8 17.0 1.0 CD1 I:ILE99 4.8 18.4 1.0

Y.Wang, J.Zhu, J.J.Liu, X.Chen, J.Mihalic, J.Deignan, M.Yu, D.Sun, F.Kayser, L.R.Mcgee, M.C.Lo, A.Chen, J.Zhou, Q.Ye, X.Huang, A.M.Long, P.Yakowec, J.D.Oliner, S.H.Olson, J.C.Medina. Optimization Beyond Amg 232: Discovery and Sar of Sulfonamides on A Piperidinone Scaffold As Potent Inhibitors of the MDM2-P53 Protein-Protein Interaction. Bioorg.Med.Chem.Lett. V. 24 3782 2014.
ISSN: ISSN 0960-894X
PubMed: 25042256
DOI: 10.1016/J.BMCL.2014.06.073