Chlorine »
PDB 4qoc-4qv4 »
4qrd »
Chlorine in PDB 4qrd: Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine
Enzymatic activity of Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine
All present enzymatic activity of Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine:
6.1.1.10;
6.1.1.10;
Protein crystallography data
The structure of Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine, PDB code: 4qrd
was solved by
X.Li,
M.T.Hilgers,
M.Stidham,
V.Brown-Driver,
K.J.Shaw,
J.Finn,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 21.25 / 1.97 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 62.438, 76.726, 118.222, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.1 / 28.3 |
Other elements in 4qrd:
The structure of Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine
(pdb code 4qrd). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine, PDB code: 4qrd:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine, PDB code: 4qrd:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 4qrd
Go back to
Chlorine Binding Sites List in 4qrd
Chlorine binding site 1 out
of 2 in the Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 4qrd
Go back to
Chlorine Binding Sites List in 4qrd
Chlorine binding site 2 out
of 2 in the Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Structure of Methionyl-Trna Synthetase in Complex with N-(1H- Benzimidazol-2-Ylmethyl)-N'-(2,4-Dichlorophenyl)-6-(Morpholin-4-Yl)- 1,3,5-Triazine-2,4-Diamine within 5.0Å range:
|
Reference:
X.Li,
M.T.Hilgers,
M.Stidham,
V.Brown-Driver,
K.J.Shaw,
J.Finn.
Discovery and Sar of A Novel Series of Pyrimidine Antibacterials Targeting Methionyl-Trna Synthetase To Be Published.
Page generated: Sat Dec 12 11:06:25 2020
Last articles
Zn in 8WB0Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
