Atomistry » Chlorine » PDB 4qv7-4qz0 » 4qv8
Atomistry »
  Chlorine »
    PDB 4qv7-4qz0 »
      4qv8 »

Chlorine in PDB 4qv8: Ycp BETA5-C52F Mutant

Enzymatic activity of Ycp BETA5-C52F Mutant

All present enzymatic activity of Ycp BETA5-C52F Mutant:
3.4.25.1;

Protein crystallography data

The structure of Ycp BETA5-C52F Mutant, PDB code: 4qv8 was solved by E.M.Huber, W.Heinemeyer, M.Groll, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 135.180, 300.700, 144.400, 90.00, 112.95, 90.00
R / Rfree (%) 19.2 / 22.1

Other elements in 4qv8:

The structure of Ycp BETA5-C52F Mutant also contains other interesting chemical elements:

Magnesium (Mg) 9 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Ycp BETA5-C52F Mutant (pdb code 4qv8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Ycp BETA5-C52F Mutant, PDB code: 4qv8:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4qv8

Go back to Chlorine Binding Sites List in 4qv8
Chlorine binding site 1 out of 2 in the Ycp BETA5-C52F Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ycp BETA5-C52F Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl302

b:36.1
occ:1.00
OH H:TYR69 2.9 37.5 1.0
NH1 G:ARG111 3.1 38.2 1.0
OD1 G:ASN114 3.2 43.5 1.0
CE2 H:TYR69 3.7 34.7 1.0
CB G:ASN114 3.7 37.9 1.0
CZ H:TYR69 3.7 35.5 1.0
CD G:ARG111 3.8 37.6 1.0
CG G:ASN114 3.8 39.8 1.0
CZ G:ARG111 4.2 38.7 1.0
NE G:ARG111 4.4 38.4 1.0
CA G:ARG111 4.7 37.5 1.0
O G:ARG111 4.8 39.3 1.0
OD2 A:ASP87 4.9 43.5 1.0
CD2 H:TYR69 5.0 34.5 1.0

Chlorine binding site 2 out of 2 in 4qv8

Go back to Chlorine Binding Sites List in 4qv8
Chlorine binding site 2 out of 2 in the Ycp BETA5-C52F Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Ycp BETA5-C52F Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
U:Cl301

b:45.2
occ:1.00
OH V:TYR69 2.9 41.6 1.0
NH1 U:ARG111 3.0 43.7 1.0
OD1 U:ASN114 3.2 48.0 1.0
CB U:ASN114 3.6 43.1 1.0
CD U:ARG111 3.7 42.1 1.0
CE2 V:TYR69 3.7 44.5 1.0
CZ V:TYR69 3.7 44.5 1.0
CG U:ASN114 3.8 45.9 1.0
CZ U:ARG111 4.1 43.2 1.0
NE U:ARG111 4.3 43.5 1.0
CA U:ARG111 4.6 40.2 1.0
O U:ARG111 4.7 40.3 1.0
OD2 O:ASP87 5.0 46.7 1.0
CG U:ARG111 5.0 41.3 1.0
ND2 U:ASN114 5.0 44.8 1.0

Reference:

E.M.Huber, W.Heinemeyer, M.Groll. Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and Onx 0914. Structure 2015.
ISSN: ISSN 0969-2126
PubMed: 25599643
DOI: 10.1016/J.STR.2014.11.019
Page generated: Fri Jul 11 21:02:24 2025

Last articles

F in 4L8M
F in 4L7J
F in 4L4M
F in 4L6Q
F in 4L7F
F in 4L4L
F in 4L46
F in 4L45
F in 4L44
F in 4L43
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy