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Atomistry » Chlorine » PDB 4r68-4rit » 4r7h | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4r68-4rit » 4r7h » |
Chlorine in PDB 4r7h: Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397Enzymatic activity of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
All present enzymatic activity of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h
was solved by
Y.Zhang,
K.Zhang,
C.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4r7h:
The structure of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
(pdb code 4r7h). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h: Chlorine binding site 1 out of 1 in 4r7hGo back to Chlorine Binding Sites List in 4r7h
Chlorine binding site 1 out
of 1 in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
Mono view Stereo pair view
Reference:
W.D.Tap,
Z.A.Wainberg,
S.P.Anthony,
P.N.Ibrahim,
C.Zhang,
J.H.Healey,
B.Chmielowski,
A.P.Staddon,
A.L.Cohn,
G.I.Shapiro,
V.L.Keedy,
A.S.Singh,
I.Puzanov,
E.L.Kwak,
A.J.Wagner,
D.D.Von Hoff,
G.J.Weiss,
R.K.Ramanathan,
J.Zhang,
G.Habets,
Y.Zhang,
E.A.Burton,
G.Visor,
L.Sanftner,
P.Severson,
H.Nguyen,
M.J.Kim,
A.Marimuthu,
G.Tsang,
R.Shellooe,
C.Gee,
B.L.West,
P.Hirth,
K.Nolop,
M.Van De Rijn,
H.H.Hsu,
C.Peterfy,
P.S.Lin,
S.Tong-Starksen,
G.Bollag.
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med V. 373 428 2015.
Page generated: Sat Dec 12 11:10:59 2020
PubMed: 26222558 DOI: 10.1056/NEJMOA1411366 |
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