Atomistry » Chlorine » PDB 4r65-4rhb » 4r7h
Atomistry »
  Chlorine »
    PDB 4r65-4rhb »
      4r7h »

Chlorine in PDB 4r7h: Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397

Enzymatic activity of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397

All present enzymatic activity of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h was solved by Y.Zhang, K.Zhang, C.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.62 / 2.80
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 63.984, 63.984, 185.041, 90.00, 90.00, 90.00
R / Rfree (%) 22.1 / 24.8

Other elements in 4r7h:

The structure of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397 also contains other interesting chemical elements:

Fluorine (F) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397 (pdb code 4r7h). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h:

Chlorine binding site 1 out of 1 in 4r7h

Go back to Chlorine Binding Sites List in 4r7h
Chlorine binding site 1 out of 1 in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1001

b:30.3
occ:1.00
CL1 A:P311001 0.0 30.3 1.0
C1 A:P311001 1.7 26.2 1.0
C5 A:P311001 2.7 25.4 1.0
C2 A:P311001 2.7 26.4 1.0
CB A:LEU588 3.7 28.3 1.0
CD2 A:LEU588 3.8 28.4 1.0
CA A:GLY669 3.9 28.1 1.0
C7 A:P311001 4.0 25.8 1.0
N4 A:P311001 4.0 26.0 1.0
CG A:LEU588 4.1 28.4 1.0
CD1 A:LEU588 4.2 26.8 1.0
O A:LEU588 4.3 29.9 1.0
C8 A:P311001 4.4 25.9 1.0
CD1 A:LEU785 4.6 26.3 1.0
CA A:LEU588 4.6 29.6 1.0
O A:CYS666 4.7 27.8 1.0
C A:LEU588 4.7 30.5 1.0
C A:GLY669 4.8 27.8 1.0
N A:GLY669 4.8 29.3 1.0
CZ A:PHE797 4.8 25.6 1.0
N A:ASP670 4.9 28.9 1.0

Reference:

W.D.Tap, Z.A.Wainberg, S.P.Anthony, P.N.Ibrahim, C.Zhang, J.H.Healey, B.Chmielowski, A.P.Staddon, A.L.Cohn, G.I.Shapiro, V.L.Keedy, A.S.Singh, I.Puzanov, E.L.Kwak, A.J.Wagner, D.D.Von Hoff, G.J.Weiss, R.K.Ramanathan, J.Zhang, G.Habets, Y.Zhang, E.A.Burton, G.Visor, L.Sanftner, P.Severson, H.Nguyen, M.J.Kim, A.Marimuthu, G.Tsang, R.Shellooe, C.Gee, B.L.West, P.Hirth, K.Nolop, M.Van De Rijn, H.H.Hsu, C.Peterfy, P.S.Lin, S.Tong-Starksen, G.Bollag. Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med V. 373 428 2015.
PubMed: 26222558
DOI: 10.1056/NEJMOA1411366
Page generated: Sat Dec 12 11:10:59 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy