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Chlorine in PDB 4ra0: An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis

Enzymatic activity of An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis

All present enzymatic activity of An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis:
2.7.10.1;

Protein crystallography data

The structure of An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis, PDB code: 4ra0 was solved by M.S.Kariolis, S.Kapur, I.I.Mathews, J.R.Cochran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.01 / 3.07
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 112.370, 112.370, 361.260, 90.00, 90.00, 120.00
R / Rfree (%) 20.2 / 24.3

Other elements in 4ra0:

The structure of An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis also contains other interesting chemical elements:

Nickel (Ni) 2 atoms
Calcium (Ca) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis (pdb code 4ra0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis, PDB code: 4ra0:

Chlorine binding site 1 out of 1 in 4ra0

Go back to Chlorine Binding Sites List in 4ra0
Chlorine binding site 1 out of 1 in the An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl704

b:99.5
occ:1.00
NH2 A:ARG446 3.6 82.5 1.0
CD1 A:TRP379 4.2 69.5 1.0
NH1 A:ARG446 4.3 83.0 1.0
CZ A:ARG446 4.4 81.0 1.0
CB A:TRP379 4.7 71.1 1.0
CG A:TRP379 4.7 67.6 1.0

Reference:

M.S.Kariolis, Y.R.Miao, D.S.Jones, S.Kapur, I.I.Mathews, A.J.Giaccia, J.R.Cochran. An Engineered Axl 'Decoy Receptor' Effectively Silences the GAS6-Axl Signaling Axis. Nat.Chem.Biol. V. 10 977 2014.
ISSN: ISSN 1552-4450
PubMed: 25242553
DOI: 10.1038/NCHEMBIO.1636
Page generated: Fri Jul 26 01:10:54 2024

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