Chlorine in PDB 4ram: Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G

All present enzymatic activity of Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G:
3.5.2.6;

The structure of Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G, PDB code: 4ram was solved by Y.Kim, C.Tesar, R.Jedrzejczak, G.Babnigg, J.Sacchettini, A.Joachimiak, Midwest Center For Structural Genomics (Mcsg), Structures Of Mtbproteins Conferring Susceptibility To Known Mtb Inhibitors (Mtbi), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.97 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.065, 79.212, 133.307, 90.00, 90.00, 90.00
R / Rfree (%)	14.3 / 18

The structure of Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G also contains other interesting chemical elements:

Zinc

(Zn)

7 atoms

The binding sites of Chlorine atom in the Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G (pdb code 4ram). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G, PDB code: 4ram:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl305 b:31.8 occ:1.00 ZN A:ZN303 2.4 12.5 1.0 O A:HOH533 3.3 31.9 1.0 OE2 A:GLU152 3.5 17.6 1.0 OE2 B:GLU227 3.6 20.2 0.9 OD1 A:ASP223 3.7 14.8 0.8 OD2 A:ASP223 3.7 14.9 1.0 CG A:ASP223 4.1 14.7 1.0 OE1 B:GLU227 4.2 19.0 0.9 CD B:GLU227 4.2 18.6 0.9 O A:HOH402 4.3 25.6 1.0 O A:HOH516 4.4 46.2 1.0 CD A:GLU152 4.4 16.5 1.0 OE1 A:GLU152 4.4 17.7 1.0 NE2 A:HIS122 4.5 12.9 1.0 CD2 A:HIS122 5.0 12.0 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl306 b:35.0 occ:1.00 ZN B:ZN303 2.3 11.2 1.0 O B:HOH545 3.3 35.1 1.0 OE2 B:GLU152 3.6 14.6 1.0 OE2 A:GLU227 3.6 18.0 1.0 OD1 B:ASP223 3.6 13.8 0.7 OD2 B:ASP223 3.6 14.2 1.0 CG B:ASP223 4.0 13.9 1.0 OE1 A:GLU227 4.1 17.3 1.0 CD A:GLU227 4.2 16.7 1.0 O B:HOH402 4.3 26.1 1.0 OE1 B:GLU152 4.4 16.4 1.0 CD B:GLU152 4.4 14.6 1.0 NE2 B:HIS122 4.6 12.5 1.0

Y.Kim, C.Tesar, R.Jedrzejczak, G.Babnigg, J.Sacchettini, A.Joachimiak, Midwest Center For Structural Genomics (Mcsg), Structures Of Mtb Proteins Conferring Susceptibility Toknown Mtb Inhibitors (Mtbi). Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G To Be Published.