Chlorine in PDB 4rdq: Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium

The structure of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium, PDB code: 4rdq was solved by V.K.Dickson, L.Pedi, S.B.Long, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.89 / 2.85
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	98.540, 242.904, 172.757, 90.00, 93.68, 90.00
R / Rfree (%)	21.7 / 23.4

The structure of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium also contains other interesting chemical elements:

Potassium	(K)	5 atoms
Calcium	(Ca)	5 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 15;

Binding sites:

The binding sites of Chlorine atom in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium (pdb code 4rdq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 15 binding sites of Chlorine where determined in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium, PDB code: 4rdq:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:67.8 occ:1.00 OG1 A:THR277 3.0 65.4 1.0 OH B:TYR68 3.0 69.4 1.0 OH B:TYR72 3.3 78.4 1.0 N A:THR277 3.4 55.4 1.0 CA A:PRO274 3.4 60.0 1.0 CB A:PRO274 3.4 56.7 1.0 C A:PRO274 3.5 62.6 1.0 CB A:THR277 3.6 60.6 1.0 O A:HOH601 3.7 66.0 1.0 CZ B:TYR72 3.7 77.0 1.0 O A:PRO274 3.8 68.1 1.0 N A:PHE276 3.9 57.0 1.0 CZ B:TYR68 3.9 64.5 1.0 CE2 B:TYR72 3.9 77.9 1.0 CE1 B:TYR68 3.9 58.6 1.0 N A:VAL275 4.0 65.7 1.0 CA A:THR277 4.1 57.3 1.0 C A:PHE276 4.2 52.8 1.0 CB A:PHE276 4.2 51.7 1.0 CA A:PHE276 4.3 54.4 1.0 CE1 B:TYR72 4.5 77.4 1.0 C A:VAL275 4.6 59.6 1.0 CZ A:PHE257 4.7 65.7 1.0 N A:PRO274 4.8 61.5 1.0 CD2 B:TYR72 4.8 76.0 1.0 CG A:PRO274 4.8 56.7 1.0 CA A:VAL275 4.9 60.9 1.0

Chlorine binding site 2 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:0.9 occ:1.00 N A:LEU75 3.4 77.3 1.0 CB A:GLU74 3.4 96.9 1.0 CG1 A:ILE76 3.4 83.4 1.0 CD1 A:ILE76 3.4 92.3 1.0 CA A:GLU74 3.5 90.8 1.0 N A:ILE76 3.5 81.1 1.0 C A:GLU74 3.7 91.2 1.0 CB A:ILE76 3.8 83.5 1.0 CD A:PRO77 4.1 78.0 1.0 CG A:GLU74 4.2 0.9 1.0 CA A:ILE76 4.3 80.9 1.0 CA A:LEU75 4.3 77.8 1.0 C A:LEU75 4.4 75.2 1.0 O A:GLU74 4.6 89.0 1.0 CB A:LEU75 4.8 82.7 1.0 N A:GLU74 4.9 84.5 1.0

Chlorine binding site 3 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl505 b:0.7 occ:1.00 OG A:SER219 3.7 50.6 1.0 CA A:SER219 3.9 48.8 1.0 NH1 A:ARG218 4.0 78.0 1.0 CG E:ARG105 4.1 61.0 1.0 CD E:ARG105 4.2 58.0 1.0 CG A:ARG218 4.3 60.0 1.0 N A:SER219 4.3 51.9 1.0 CB A:SER219 4.4 45.7 1.0 O A:ARG218 4.4 61.4 1.0 CZ A:ARG218 4.4 74.4 1.0 C A:ARG218 4.5 61.2 1.0 CB E:TRP102 4.5 68.1 1.0 CB E:ASP104 4.6 63.3 1.0 NH2 A:ARG218 4.8 76.7 1.0 NE A:ARG218 5.0 70.8 1.0

Chlorine binding site 4 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl503 b:0.8 occ:1.00 OG B:SER219 3.7 50.8 1.0 CA B:SER219 3.9 52.1 1.0 NH1 B:ARG218 4.0 72.9 1.0 CG A:ARG105 4.1 60.0 1.0 CD A:ARG105 4.2 56.3 1.0 CG B:ARG218 4.3 56.9 1.0 N B:SER219 4.3 55.4 1.0 O B:ARG218 4.3 59.3 1.0 CB B:SER219 4.4 49.4 1.0 CZ B:ARG218 4.4 70.4 1.0 C B:ARG218 4.5 57.4 1.0 CB A:TRP102 4.6 67.7 1.0 CB A:ASP104 4.6 67.0 1.0 NH2 B:ARG218 4.8 74.2 1.0 NE B:ARG218 4.9 67.5 1.0

Chlorine binding site 5 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl504 b:69.2 occ:1.00 OH C:TYR68 2.9 69.5 1.0 OG1 B:THR277 3.0 68.5 1.0 OH C:TYR72 3.4 75.8 1.0 N B:THR277 3.4 60.4 1.0 CA B:PRO274 3.4 69.1 1.0 CB B:PRO274 3.5 66.6 1.0 C B:PRO274 3.5 72.0 1.0 O B:HOH601 3.7 67.6 1.0 CZ C:TYR72 3.7 74.5 1.0 CB B:THR277 3.7 65.5 1.0 CZ C:TYR68 3.8 64.2 1.0 N B:PHE276 3.8 61.4 1.0 CE1 C:TYR68 3.8 57.7 1.0 O B:PRO274 3.8 77.2 1.0 CE2 C:TYR72 3.9 75.5 1.0 N B:VAL275 4.0 67.2 1.0 CA B:THR277 4.1 60.6 1.0 CB B:PHE276 4.2 55.1 1.0 C B:PHE276 4.2 56.3 1.0 CA B:PHE276 4.2 58.1 1.0 CE1 C:TYR72 4.5 74.1 1.0 C B:VAL275 4.6 62.3 1.0 CZ B:PHE257 4.7 66.8 1.0 CD2 C:TYR72 4.8 73.6 1.0 N B:PRO274 4.8 69.9 1.0 CA B:VAL275 4.9 62.0 1.0 CG B:PRO274 4.9 66.5 1.0

Chlorine binding site 6 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl505 b:0.1 occ:1.00 N B:LEU75 3.4 79.7 1.0 CB B:GLU74 3.4 97.7 1.0 CG1 B:ILE76 3.4 77.4 1.0 CD1 B:ILE76 3.4 85.3 1.0 CA B:GLU74 3.5 92.6 1.0 N B:ILE76 3.5 76.1 1.0 C B:GLU74 3.6 92.3 1.0 CB B:ILE76 3.7 77.5 1.0 CD B:PRO77 4.1 79.4 1.0 CA B:ILE76 4.2 75.6 1.0 CG B:GLU74 4.2 0.3 1.0 CA B:LEU75 4.3 81.2 1.0 C B:LEU75 4.4 78.8 1.0 O B:GLU74 4.6 91.1 1.0 CB B:LEU75 4.8 85.7 1.0 N B:GLU74 4.8 87.3 1.0

Chlorine binding site 7 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl503 b:0.8 occ:1.00 OG C:SER219 3.6 52.8 1.0 CA C:SER219 3.8 50.3 1.0 NH1 C:ARG218 4.0 70.7 1.0 CG B:ARG105 4.1 64.1 1.0 N C:SER219 4.2 53.0 1.0 CD B:ARG105 4.3 60.6 1.0 CG C:ARG218 4.3 53.0 1.0 CB C:SER219 4.3 48.1 1.0 O C:ARG218 4.3 54.6 1.0 CZ C:ARG218 4.4 67.5 1.0 C C:ARG218 4.5 52.2 1.0 CB B:TRP102 4.6 71.8 1.0 CB B:ASP104 4.6 72.0 1.0 NH2 C:ARG218 4.8 71.9 1.0 NE C:ARG218 4.9 63.1 1.0 C C:SER219 5.0 52.3 1.0

Chlorine binding site 8 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl504 b:66.1 occ:1.00 OH D:TYR68 2.9 68.9 1.0 OG1 C:THR277 3.0 67.5 1.0 N C:THR277 3.4 57.3 1.0 OH D:TYR72 3.4 78.4 1.0 CA C:PRO274 3.4 60.5 1.0 CB C:PRO274 3.4 57.4 1.0 C C:PRO274 3.5 64.0 1.0 CB C:THR277 3.7 62.8 1.0 CZ D:TYR72 3.7 75.5 1.0 O C:HOH601 3.7 67.1 1.0 N C:PHE276 3.8 57.0 1.0 O C:PRO274 3.8 68.6 1.0 CZ D:TYR68 3.8 63.7 1.0 CE1 D:TYR68 3.9 58.2 1.0 CE2 D:TYR72 3.9 76.4 1.0 N C:VAL275 4.0 64.5 1.0 CA C:THR277 4.1 58.5 1.0 CB C:PHE276 4.2 52.0 1.0 C C:PHE276 4.2 54.3 1.0 CA C:PHE276 4.2 54.8 1.0 CE1 D:TYR72 4.5 75.2 1.0 C C:VAL275 4.6 55.7 1.0 CZ C:PHE257 4.7 67.3 1.0 N C:PRO274 4.8 61.0 1.0 CD2 D:TYR72 4.8 73.6 1.0 CG C:PRO274 4.9 57.7 1.0 CA C:VAL275 4.9 57.8 1.0

Chlorine binding site 9 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl505 b:0.1 occ:1.00 N C:LEU75 3.4 85.5 1.0 CB C:GLU74 3.4 90.5 1.0 CG1 C:ILE76 3.4 80.4 1.0 CD1 C:ILE76 3.4 88.3 1.0 CA C:GLU74 3.5 85.2 1.0 N C:ILE76 3.5 78.6 1.0 C C:GLU74 3.7 85.3 1.0 CB C:ILE76 3.7 80.6 1.0 CD C:PRO77 4.1 83.1 1.0 CA C:ILE76 4.2 77.8 1.0 CG C:GLU74 4.3 0.3 1.0 CA C:LEU75 4.3 85.5 1.0 C C:LEU75 4.4 83.1 1.0 O C:GLU74 4.6 82.7 1.0 CB C:LEU75 4.8 89.5 1.0 N C:GLU74 4.9 79.8 1.0

Chlorine binding site 10 out of 15 in the Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Calcium-Activated Chloride Channel Bestrophin-1, From Chicken, in Complex with Fab Antibody Fragments, Chloride and Calcium within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl503 b:1.0 occ:1.00 OG D:SER219 3.7 51.1 1.0 CA D:SER219 3.8 49.2 1.0 NH1 D:ARG218 4.0 77.1 1.0 CG C:ARG105 4.2 62.9 1.0 N D:SER219 4.3 51.1 1.0 CD C:ARG105 4.3 61.5 1.0 CB D:SER219 4.3 46.8 1.0 O D:ARG218 4.3 62.2 1.0 CG D:ARG218 4.3 61.6 1.0 CZ D:ARG218 4.4 74.7 1.0 C D:ARG218 4.5 60.0 1.0 CB C:TRP102 4.6 69.2 1.0 CB C:ASP104 4.7 62.1 1.0 NH2 D:ARG218 4.8 77.7 1.0 C D:SER219 4.9 51.2 1.0 NE D:ARG218 5.0 70.6 1.0

V.K.Dickson, L.Pedi, S.B.Long. Structure and Insights Into the Function of A CA2+ -Activated Cl- Channel Nature 2014.
ISSN: ESSN 1476-4687
DOI: 10.1038/NATURE13913