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Chlorine in PDB 4rrx: Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with LumiracoxibEnzymatic activity of Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib
All present enzymatic activity of Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib:
1.14.99.1; Protein crystallography data
The structure of Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib, PDB code: 4rrx
was solved by
S.Xu,
A.L.Blobaum,
S.Banerjee,
L.J.Marnett,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4rrx:
The structure of Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib
(pdb code 4rrx). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib, PDB code: 4rrx: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4rrxGo back to Chlorine Binding Sites List in 4rrx
Chlorine binding site 1 out
of 2 in the Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4rrxGo back to Chlorine Binding Sites List in 4rrx
Chlorine binding site 2 out
of 2 in the Crystal Structure of Apo Murine V89W Cyclooxygenase-2 Complexed with Lumiracoxib
Mono view Stereo pair view
Reference:
A.L.Blobaum,
S.Xu,
S.W.Rowlinson,
K.C.Duggan,
S.Banerjee,
S.N.Kudalkar,
W.R.Birmingham,
K.Ghebreselasie,
L.J.Marnett.
Action at A Distance: Mutations of Peripheral Residues Transform Rapid Reversible Inhibitors to Slow, Tight Binders of Cyclooxygenase-2. J.Biol.Chem. 2015.
Page generated: Sat Dec 12 11:12:07 2020
ISSN: ESSN 1083-351X DOI: 10.1074/JBC.M114.635987 |
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