Chlorine in PDB 4tnv: C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation

The structure of C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation, PDB code: 4tnv was solved by T.Althoff, R.E.Hibbs, S.Banerjee, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.44 / 3.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	455.810, 195.680, 196.180, 90.00, 93.15, 90.00
R / Rfree (%)	26.1 / 28.3

The binding sites of Chlorine atom in the C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation (pdb code 4tnv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation, PDB code: 4tnv:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation within 5.0Å range: probe atom residue distance (Å) B Occ P:Cl403 b:0.7 occ:1.00 CB T:ALA258 4.4 95.0 1.0 CB S:ALA258 4.7 96.9 1.0 CB P:ALA258 4.8 0.3 1.0

Chlorine binding site 2 out of 2 in the C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of C. Elegans Glutamate-Gated Chloride Channel (Glucl) in Complex with Fab in A Non-Conducting Conformation within 5.0Å range: probe atom residue distance (Å) B Occ P:Cl404 b:0.7 occ:1.00 OG1 Q:THR251 4.5 0.0 1.0 OG1 P:THR251 4.6 0.3 1.0 CG2 Q:THR247 4.8 0.8 1.0 CG2 P:THR247 4.9 0.8 1.0

T.Althoff, R.E.Hibbs, S.Banerjee, E.Gouaux. X-Ray Structures of Glucl in Apo States Reveal A Gating Mechanism of Cys-Loop Receptors. Nature V. 512 333 2014.
ISSN: ESSN 1476-4687
PubMed: 25143115
DOI: 10.1038/NATURE13669