Chlorine in PDB 4tqc: The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G

The structure of The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G, PDB code: 4tqc was solved by E.Papadopoulos, S.Jenni, G.Wagner, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.50 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	40.210, 73.640, 66.980, 90.00, 74.92, 90.00
R / Rfree (%)	16.1 / 19.4

The binding sites of Chlorine atom in the The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G (pdb code 4tqc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G, PDB code: 4tqc:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:61.7 occ:1.00 CL17 A:34J302 0.0 61.7 1.0 C16 A:34J302 1.7 51.7 1.0 C18 A:34J302 2.7 53.2 1.0 C15 A:34J302 2.7 49.9 1.0 H151 A:34J302 2.8 59.8 1.0 HE1 A:HIS78 2.9 36.4 1.0 CL19 A:34J302 3.1 55.1 1.0 CE1 A:HIS78 3.4 30.4 1.0 ND1 A:HIS78 3.5 37.4 1.0 HG12 A:ILE79 3.8 53.1 1.0 HG13 A:ILE79 3.9 53.1 1.0 C20 A:34J302 4.0 50.0 1.0 C14 A:34J302 4.0 50.8 1.0 HG21 A:ILE63 4.0 67.6 1.0 HD11 A:ILE79 4.1 53.2 1.0 HD11 A:LEU75 4.2 32.6 1.0 CG1 A:ILE79 4.2 44.2 1.0 HD12 A:LEU75 4.4 32.6 1.0 C13 A:34J302 4.5 48.0 1.0 HZ A:PHE47 4.5 41.2 1.0 HG23 A:ILE63 4.5 67.6 1.0 CG2 A:ILE63 4.6 56.4 1.0 HG22 A:ILE63 4.6 67.6 1.0 NE2 A:HIS78 4.7 52.4 1.0 CD1 A:ILE79 4.7 44.3 1.0 CD1 A:LEU75 4.7 27.1 1.0 H201 A:34J302 4.7 60.0 1.0 H141 A:34J302 4.8 61.0 1.0 CG A:HIS78 4.8 36.8 1.0

Chlorine binding site 2 out of 2 in the The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Co-Complex Structure of the Translation Initiation Factor EIF4E with the Inhibitor 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:55.1 occ:1.00 CL19 A:34J302 0.0 55.1 1.0 C18 A:34J302 1.8 53.2 1.0 HB2 A:SER82 2.6 91.7 1.0 C16 A:34J302 2.7 51.7 1.0 C20 A:34J302 2.7 50.0 1.0 H201 A:34J302 2.9 60.0 1.0 CL17 A:34J302 3.1 61.7 1.0 HB3 A:SER82 3.1 91.7 1.0 HE1 A:HIS78 3.2 36.4 1.0 CB A:SER82 3.3 76.4 1.0 HA A:ILE79 3.3 55.6 1.0 CE1 A:HIS78 3.4 30.4 1.0 HG12 A:ILE79 3.5 53.1 1.0 ND1 A:HIS78 3.8 37.4 1.0 NE2 A:HIS78 3.9 52.4 1.0 C15 A:34J302 4.0 49.9 1.0 HG13 A:ILE79 4.0 53.1 1.0 C13 A:34J302 4.0 48.0 1.0 HE2 A:HIS78 4.1 62.8 1.0 CG1 A:ILE79 4.2 44.2 1.0 C A:SER82 4.3 69.6 1.0 OG A:SER82 4.3 73.6 1.0 CA A:ILE79 4.3 46.4 1.0 CA A:SER82 4.4 67.9 1.0 O A:HIS78 4.4 29.1 1.0 CG A:HIS78 4.5 36.8 1.0 C14 A:34J302 4.5 50.8 1.0 CD2 A:HIS78 4.5 37.2 1.0 HG23 A:ILE79 4.6 67.1 1.0 HG A:SER82 4.6 88.3 1.0 H151 A:34J302 4.7 59.8 1.0 N A:ILE79 4.7 44.2 1.0 C A:HIS78 4.8 25.7 1.0 CB A:ILE79 4.8 45.0 1.0 O A:SER82 4.9 85.6 1.0 H211 A:34J302 4.9 65.0 1.0 H A:SER82 5.0 68.2 1.0

E.Papadopoulos, S.Jenni, E.Kabha, K.J.Takrouri, T.Yi, N.Salvi, R.E.Luna, E.Gavathiotis, P.Mahalingam, H.Arthanari, R.Rodriguez-Mias, R.Yefidoff-Freedman, B.H.Aktas, M.Chorev, J.A.Halperin, G.Wagner. Structure of the Eukaryotic Translation Initiation Factor EIF4E in Complex with 4EGI-1 Reveals An Allosteric Mechanism For Dissociating EIF4G. Proc.Natl.Acad.Sci.Usa V. 111 E3187 2014.
ISSN: ESSN 1091-6490
PubMed: 25049413
DOI: 10.1073/PNAS.1410250111