Chlorine in PDB 4tsz: Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand

All present enzymatic activity of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand:
2.7.7.7;

The structure of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand, PDB code: 4tsz was solved by V.Olieric, D.Burnouf, E.Ennifar, P.Wolff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.28 / 2.00
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	79.982, 85.947, 272.202, 90.01, 89.94, 116.56
R / Rfree (%)	20.2 / 22.2

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 32;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand (pdb code 4tsz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 32 binding sites of Chlorine where determined in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand, PDB code: 4tsz:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ Q:Cl472 b:53.4 occ:1.00 CLZ Q:ZCL472 0.0 53.4 1.0 CZ Q:ZCL472 1.7 56.3 1.0 CE2 Q:ZCL472 2.7 56.8 1.0 CE1 Q:ZCL472 2.7 56.9 1.0 CLE1 Q:ZCL472 3.2 61.6 1.0 CA A:TYR245 3.6 32.6 1.0 CG2 A:VAL248 3.7 37.6 1.0 CB A:PRO243 3.8 39.8 1.0 CB A:TYR245 3.8 31.3 1.0 CD2 Q:ZCL472 4.0 58.4 1.0 CD1 Q:ZCL472 4.0 54.5 1.0 N A:TYR245 4.1 35.9 1.0 CG2 A:THR172 4.2 30.4 1.0 CG A:PRO243 4.2 43.0 1.0 CD1 A:LEU177 4.3 26.0 1.0 CG Q:ZCL472 4.5 55.6 1.0 C A:ASP244 4.6 40.8 1.0 C A:PRO243 4.7 42.4 1.0 O A:PRO243 4.7 40.9 1.0 O A:ASP244 4.7 40.2 1.0 CG1 A:VAL248 4.8 40.8 1.0 CA A:PRO243 4.8 38.9 1.0 OG1 A:THR172 4.8 30.3 1.0 C A:TYR245 4.8 34.2 1.0 CB A:VAL248 4.8 39.7 1.0 CB A:THR172 4.9 28.6 1.0 CD A:PRO243 5.0 38.0 1.0 O A:TYR245 5.0 31.0 1.0

Chlorine binding site 2 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ Q:Cl472 b:61.6 occ:1.00 CLE1 Q:ZCL472 0.0 61.6 1.0 CE1 Q:ZCL472 1.7 56.9 1.0 CD1 Q:ZCL472 2.7 54.5 1.0 CZ Q:ZCL472 2.7 56.3 1.0 CLZ Q:ZCL472 3.2 53.4 1.0 OG1 A:THR172 3.3 30.3 1.0 CG2 A:THR172 3.5 30.4 1.0 CA A:GLY174 3.6 28.4 1.0 N A:GLY174 3.8 27.4 1.0 CB A:THR172 4.0 28.6 1.0 CG Q:ZCL472 4.0 55.6 1.0 CE2 Q:ZCL472 4.0 56.8 1.0 CB Q:LEU471 4.1 34.9 1.0 CD1 Q:LEU471 4.2 37.7 1.0 CD2 Q:ZCL472 4.5 58.4 1.0 CD2 A:LEU155 4.5 34.9 1.0 C A:GLY174 4.5 33.6 1.0 CD1 A:LEU155 4.6 31.5 1.0 CG A:PRO243 4.7 43.0 1.0 CG Q:LEU471 4.8 38.4 1.0 O A:GLY174 4.8 37.0 1.0 O A:HOH457 4.9 18.5 0.5 C A:ASP173 4.9 29.8 1.0

Chlorine binding site 3 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl472 b:51.8 occ:1.00 CLZ R:ZCL472 0.0 51.8 1.0 CZ R:ZCL472 1.7 55.3 1.0 CE2 R:ZCL472 2.7 55.6 1.0 CE1 R:ZCL472 2.7 57.9 1.0 CLE1 R:ZCL472 3.2 63.6 1.0 CA B:TYR245 3.6 31.1 1.0 CG2 B:VAL248 3.6 44.4 1.0 CB B:PRO243 3.7 36.0 1.0 CB B:TYR245 3.8 29.6 1.0 CD2 R:ZCL472 4.0 56.9 1.0 CD1 R:ZCL472 4.0 55.4 1.0 N B:TYR245 4.1 32.6 1.0 CG2 B:THR172 4.2 29.5 1.0 CG B:PRO243 4.2 38.7 1.0 CD1 B:LEU177 4.2 26.2 1.0 CG R:ZCL472 4.5 55.5 1.0 C B:ASP244 4.6 38.8 1.0 C B:PRO243 4.7 38.0 1.0 O B:PRO243 4.7 36.7 1.0 CG1 B:VAL248 4.7 47.3 1.0 O B:ASP244 4.7 39.3 1.0 CB B:VAL248 4.8 46.2 1.0 CA B:PRO243 4.8 34.4 1.0 OG1 B:THR172 4.8 29.3 1.0 C B:TYR245 4.8 36.5 1.0 CB B:THR172 4.9 27.5 1.0 O B:TYR245 5.0 33.8 1.0 CD B:PRO243 5.0 33.7 1.0

Chlorine binding site 4 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl472 b:63.6 occ:1.00 CLE1 R:ZCL472 0.0 63.6 1.0 CE1 R:ZCL472 1.7 57.9 1.0 CD1 R:ZCL472 2.7 55.4 1.0 CZ R:ZCL472 2.7 55.3 1.0 CLZ R:ZCL472 3.2 51.8 1.0 OG1 B:THR172 3.3 29.3 1.0 CG2 B:THR172 3.4 29.5 1.0 CA B:GLY174 3.6 32.5 1.0 N B:GLY174 3.8 30.2 1.0 CB B:THR172 4.0 27.5 1.0 CG R:ZCL472 4.0 55.5 1.0 CE2 R:ZCL472 4.0 55.6 1.0 CB R:LEU471 4.1 39.6 1.0 CD1 R:LEU471 4.2 40.5 1.0 CD2 R:ZCL472 4.5 56.9 1.0 CD2 B:LEU155 4.5 39.5 1.0 C B:GLY174 4.6 37.6 1.0 CD1 B:LEU155 4.6 36.1 1.0 CG B:PRO243 4.7 38.7 1.0 O B:HOH563 4.8 44.7 1.0 CG R:LEU471 4.8 41.8 1.0 O B:GLY174 4.8 38.7 1.0 C B:ASP173 5.0 32.2 1.0 CB B:PRO243 5.0 36.0 1.0

Chlorine binding site 5 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ S:Cl472 b:83.6 occ:1.00 CLZ S:ZCL472 0.0 83.6 1.0 CZ S:ZCL472 1.7 87.2 1.0 CE2 S:ZCL472 2.7 89.7 1.0 CE1 S:ZCL472 2.7 87.4 1.0 CLE1 S:ZCL472 3.2 87.5 1.0 CA C:TYR245 3.6 60.2 1.0 CG2 C:VAL248 3.7 65.6 1.0 CB C:PRO243 3.7 55.2 1.0 CB C:TYR245 3.9 59.6 1.0 CD2 S:ZCL472 4.0 91.3 1.0 CD1 S:ZCL472 4.0 88.2 1.0 N C:TYR245 4.1 60.8 1.0 CG2 C:THR172 4.1 46.0 1.0 CG C:PRO243 4.2 58.1 1.0 CD1 C:LEU177 4.3 46.6 1.0 CG S:ZCL472 4.5 90.5 1.0 C C:ASP244 4.6 64.7 1.0 C C:PRO243 4.6 57.5 1.0 O C:ASP244 4.7 65.1 1.0 CG1 C:VAL248 4.7 67.9 1.0 O C:PRO243 4.7 54.0 1.0 CA C:PRO243 4.8 54.2 1.0 CB C:VAL248 4.8 67.3 1.0 OG1 C:THR172 4.8 45.7 1.0 C C:TYR245 4.8 66.6 1.0 CB C:THR172 4.9 48.5 1.0 O C:TYR245 4.9 65.3 1.0 CD C:PRO243 5.0 53.0 1.0

Chlorine binding site 6 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ S:Cl472 b:87.5 occ:1.00 CLE1 S:ZCL472 0.0 87.5 1.0 CE1 S:ZCL472 1.7 87.4 1.0 CD1 S:ZCL472 2.7 88.2 1.0 CZ S:ZCL472 2.7 87.2 1.0 CLZ S:ZCL472 3.2 83.6 1.0 OG1 C:THR172 3.2 45.7 1.0 CG2 C:THR172 3.5 46.0 1.0 CA C:GLY174 3.6 40.9 1.0 N C:GLY174 3.8 40.0 1.0 CB C:THR172 3.9 48.5 1.0 CG S:ZCL472 4.0 90.5 1.0 CE2 S:ZCL472 4.0 89.7 1.0 CB S:LEU471 4.1 52.2 1.0 CD1 S:LEU471 4.1 53.4 1.0 CD2 S:ZCL472 4.5 91.3 1.0 C C:GLY174 4.6 45.7 1.0 CD2 C:LEU155 4.6 44.9 1.0 CD1 C:LEU155 4.6 46.1 1.0 CG C:PRO243 4.7 58.1 1.0 CG S:LEU471 4.8 55.1 1.0 O C:GLY174 4.9 47.8 1.0 C C:ASP173 4.9 42.4 1.0

Chlorine binding site 7 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ T:Cl472 b:86.3 occ:1.00 CLZ T:ZCL472 0.0 86.3 1.0 CZ T:ZCL472 1.7 88.8 1.0 CE2 T:ZCL472 2.7 88.8 1.0 CE1 T:ZCL472 2.7 90.6 1.0 CLE1 T:ZCL472 3.2 92.5 1.0 CA D:TYR245 3.6 45.6 1.0 CG2 D:VAL248 3.7 62.7 1.0 CB D:PRO243 3.7 50.0 1.0 CB D:TYR245 3.8 44.3 1.0 CD2 T:ZCL472 4.0 90.0 1.0 CD1 T:ZCL472 4.0 90.0 1.0 N D:TYR245 4.1 46.8 1.0 CG2 D:THR172 4.2 45.6 1.0 CG D:PRO243 4.2 52.7 1.0 CD1 D:LEU177 4.3 41.2 1.0 CG T:ZCL472 4.5 90.2 1.0 C D:ASP244 4.6 53.1 1.0 C D:PRO243 4.7 54.0 1.0 O D:PRO243 4.7 53.5 1.0 CG1 D:VAL248 4.7 65.0 1.0 O D:ASP244 4.7 53.1 1.0 CA D:PRO243 4.8 48.8 1.0 CB D:VAL248 4.8 64.8 1.0 C D:TYR245 4.8 51.6 1.0 OG1 D:THR172 4.8 47.5 1.0 CB D:THR172 4.9 47.2 1.0 O D:TYR245 4.9 50.5 1.0 CD D:PRO243 5.0 47.6 1.0

Chlorine binding site 8 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ T:Cl472 b:92.5 occ:1.00 CLE1 T:ZCL472 0.0 92.5 1.0 CE1 T:ZCL472 1.7 90.6 1.0 CD1 T:ZCL472 2.7 90.0 1.0 CZ T:ZCL472 2.7 88.8 1.0 CLZ T:ZCL472 3.2 86.3 1.0 OG1 D:THR172 3.2 47.5 1.0 CG2 D:THR172 3.5 45.6 1.0 CA D:GLY174 3.6 40.0 1.0 N D:GLY174 3.8 39.4 1.0 CB D:THR172 3.9 47.2 1.0 CG T:ZCL472 4.0 90.2 1.0 CE2 T:ZCL472 4.0 88.8 1.0 CB T:LEU471 4.1 61.8 1.0 CD1 T:LEU471 4.1 63.0 1.0 CD2 T:ZCL472 4.5 90.0 1.0 CD2 D:LEU155 4.6 44.4 1.0 C D:GLY174 4.6 45.4 1.0 CD1 D:LEU155 4.6 44.9 1.0 CG D:PRO243 4.7 52.7 1.0 CG T:LEU471 4.8 65.1 1.0 O D:GLY174 4.8 46.3 1.0 C D:ASP173 5.0 41.5 1.0

Chlorine binding site 9 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl472 b:52.9 occ:1.00 CLZ U:ZCL472 0.0 52.9 1.0 CZ U:ZCL472 1.7 52.2 1.0 CE2 U:ZCL472 2.7 50.7 1.0 CE1 U:ZCL472 2.7 52.6 1.0 CLE1 U:ZCL472 3.2 55.1 1.0 CA E:TYR245 3.6 44.9 1.0 CG2 E:VAL248 3.7 49.7 1.0 CB E:PRO243 3.7 45.5 1.0 CB E:TYR245 3.9 44.7 1.0 CD2 U:ZCL472 4.0 50.7 1.0 CD1 U:ZCL472 4.0 50.8 1.0 N E:TYR245 4.1 45.0 1.0 CG E:PRO243 4.1 48.2 1.0 CG2 E:THR172 4.1 35.6 1.0 CD1 E:LEU177 4.4 40.3 1.0 CG U:ZCL472 4.5 50.3 1.0 C E:ASP244 4.5 48.6 1.0 O E:ASP244 4.7 48.0 1.0 C E:PRO243 4.7 49.0 1.0 CG1 E:VAL248 4.7 52.2 1.0 O E:PRO243 4.8 47.9 1.0 C E:TYR245 4.8 51.2 1.0 CA E:PRO243 4.8 44.1 1.0 CB E:VAL248 4.8 51.4 1.0 OG1 E:THR172 4.9 34.4 1.0 CD E:PRO243 4.9 42.7 1.0 O E:TYR245 4.9 50.8 1.0 CB E:THR172 5.0 40.3 1.0

Chlorine binding site 10 out of 32 in the Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of Dna Polymerase Sliding Clamp From Pseudomonas Aeruginosa with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl472 b:55.1 occ:1.00 CLE1 U:ZCL472 0.0 55.1 1.0 CE1 U:ZCL472 1.7 52.6 1.0 CD1 U:ZCL472 2.7 50.8 1.0 CZ U:ZCL472 2.7 52.2 1.0 CLZ U:ZCL472 3.2 52.9 1.0 OG1 E:THR172 3.3 34.4 1.0 CG2 E:THR172 3.5 35.6 1.0 CA E:GLY174 3.6 32.6 1.0 N E:GLY174 3.8 32.0 1.0 CB E:THR172 4.0 40.3 1.0 CG U:ZCL472 4.0 50.3 1.0 CE2 U:ZCL472 4.0 50.7 1.0 CB U:LEU471 4.1 38.6 1.0 CD1 U:LEU471 4.2 39.3 1.0 CG2 A:VAL151 4.5 43.1 1.0 CD2 U:ZCL472 4.5 50.7 1.0 CD1 E:LEU155 4.5 39.0 1.0 O E:HOH447 4.6 39.1 1.0 CD2 E:LEU155 4.6 41.5 1.0 C E:GLY174 4.6 39.9 1.0 CG U:LEU471 4.8 42.0 1.0 CG E:PRO243 4.8 48.2 1.0 O E:GLY174 4.9 40.8 1.0 C E:ASP173 5.0 37.1 1.0

P.Wolff, I.Amal, V.Olieric, O.Chaloin, G.Gygli, E.Ennifar, B.Lorber, G.Guichard, J.E.Wagner, A.Dejaegere, D.Y.Burnouf. Differential Modes of Peptide Binding Onto Replicative Sliding Clamps From Various Bacterial Origins. J.Med.Chem. 2014.
ISSN: ISSN 0022-2623
PubMed: 25170813
DOI: 10.1021/JM500467A