Chlorine in PDB 4tv8: Tubulin-Maytansine Complex

The structure of Tubulin-Maytansine Complex, PDB code: 4tv8 was solved by A.E.Prota, K.Bargsten, J.F.Diaz, M.Marsh, C.Cuevas, M.Liniger, C.Neuhaus, J.M.Andreu, K.H.Altmann, M.O.Steinmetz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.42 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	103.860, 155.570, 180.620, 90.00, 90.00, 90.00
R / Rfree (%)	18.9 / 21.9

The structure of Tubulin-Maytansine Complex also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Calcium	(Ca)	4 atoms

The binding sites of Chlorine atom in the Tubulin-Maytansine Complex (pdb code 4tv8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Tubulin-Maytansine Complex, PDB code: 4tv8:

Chlorine binding site 1 out of 1 in the Tubulin-Maytansine Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Tubulin-Maytansine Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl502 b:0.1 occ:1.00 CL1 D:3GT502 0.0 0.1 1.0 CAC D:3GT502 1.8 96.8 1.0 CAB D:3GT502 2.8 97.0 1.0 CAD D:3GT502 2.8 96.7 1.0 OAK D:3GT502 3.0 98.3 1.0 NAN D:3GT502 3.0 96.3 1.0 CAP D:3GT502 3.5 92.3 1.0 CAO D:3GT502 3.6 95.8 1.0 CZ D:PHE404 3.6 0.0 1.0 CG2 D:VAL181 3.8 85.6 1.0 CE2 D:PHE404 3.8 0.8 1.0 CAL D:3GT502 3.8 98.8 1.0 CAQ D:3GT502 3.9 87.8 1.0 CAE D:3GT502 4.0 95.3 1.0 CAA D:3GT502 4.1 96.3 1.0 OAR D:3GT502 4.3 93.2 1.0 CB D:VAL181 4.3 88.5 1.0 CAF D:3GT502 4.6 94.2 1.0 CE1 D:PHE404 4.7 0.9 1.0 CG1 D:VAL181 4.8 92.9 1.0

A.E.Prota, K.Bargsten, J.F.Diaz, M.Marsh, C.Cuevas, M.Liniger, C.Neuhaus, J.M.Andreu, K.H.Altmann, M.O.Steinmetz. A New Tubulin-Binding Site and Pharmacophore For Microtubule-Destabilizing Anticancer Drugs. Proc.Natl.Acad.Sci.Usa V. 111 13817 2014.
ISSN: ESSN 1091-6490
PubMed: 25114240
DOI: 10.1073/PNAS.1408124111