Atomistry » Chlorine » PDB 4tr9-4u19 » 4tv8
Atomistry »
  Chlorine »
    PDB 4tr9-4u19 »
      4tv8 »

Chlorine in PDB 4tv8: Tubulin-Maytansine Complex

Protein crystallography data

The structure of Tubulin-Maytansine Complex, PDB code: 4tv8 was solved by A.E.Prota, K.Bargsten, J.F.Diaz, M.Marsh, C.Cuevas, M.Liniger, C.Neuhaus, J.M.Andreu, K.H.Altmann, M.O.Steinmetz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 62.42 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 103.860, 155.570, 180.620, 90.00, 90.00, 90.00
R / Rfree (%) 18.9 / 21.9

Other elements in 4tv8:

The structure of Tubulin-Maytansine Complex also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms
Calcium (Ca) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Tubulin-Maytansine Complex (pdb code 4tv8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Tubulin-Maytansine Complex, PDB code: 4tv8:

Chlorine binding site 1 out of 1 in 4tv8

Go back to Chlorine Binding Sites List in 4tv8
Chlorine binding site 1 out of 1 in the Tubulin-Maytansine Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Tubulin-Maytansine Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl502

b:0.1
occ:1.00
CL1 D:3GT502 0.0 0.1 1.0
CAC D:3GT502 1.8 96.8 1.0
CAB D:3GT502 2.8 97.0 1.0
CAD D:3GT502 2.8 96.7 1.0
OAK D:3GT502 3.0 98.3 1.0
NAN D:3GT502 3.0 96.3 1.0
CAP D:3GT502 3.5 92.3 1.0
CAO D:3GT502 3.6 95.8 1.0
CZ D:PHE404 3.6 0.0 1.0
CG2 D:VAL181 3.8 85.6 1.0
CE2 D:PHE404 3.8 0.8 1.0
CAL D:3GT502 3.8 98.8 1.0
CAQ D:3GT502 3.9 87.8 1.0
CAE D:3GT502 4.0 95.3 1.0
CAA D:3GT502 4.1 96.3 1.0
OAR D:3GT502 4.3 93.2 1.0
CB D:VAL181 4.3 88.5 1.0
CAF D:3GT502 4.6 94.2 1.0
CE1 D:PHE404 4.7 0.9 1.0
CG1 D:VAL181 4.8 92.9 1.0

Reference:

A.E.Prota, K.Bargsten, J.F.Diaz, M.Marsh, C.Cuevas, M.Liniger, C.Neuhaus, J.M.Andreu, K.H.Altmann, M.O.Steinmetz. A New Tubulin-Binding Site and Pharmacophore For Microtubule-Destabilizing Anticancer Drugs. Proc.Natl.Acad.Sci.Usa V. 111 13817 2014.
ISSN: ESSN 1091-6490
PubMed: 25114240
DOI: 10.1073/PNAS.1408124111
Page generated: Sat Dec 12 11:13:59 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy