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Atomistry » Chlorine » PDB 4tr9-4u19 » 4tw9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4tr9-4u19 » 4tw9 » |
Chlorine in PDB 4tw9: Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell ProliferationEnzymatic activity of Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation
All present enzymatic activity of Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation:
2.7.11.1; 2.7.11.26; Protein crystallography data
The structure of Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation, PDB code: 4tw9
was solved by
J.Richter,
J.Bischof,
M.Zaja,
H.Kohlhof,
O.Othersen,
D.Vitt,
V.Alscher,
I.Pospiech,
B.Garcia-Reyes,
S.Berg,
J.Leban,
U.Knippschild,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4tw9:
The structure of Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation
(pdb code 4tw9). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation, PDB code: 4tw9: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4tw9Go back to Chlorine Binding Sites List in 4tw9
Chlorine binding site 1 out
of 2 in the Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4tw9Go back to Chlorine Binding Sites List in 4tw9
Chlorine binding site 2 out
of 2 in the Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1DELTA and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation
Mono view Stereo pair view
Reference:
J.Richter,
J.Bischof,
M.Zaja,
H.Kohlhof,
O.Othersen,
D.Vitt,
V.Alscher,
I.Pospiech,
B.Garcia-Reyes,
S.Berg,
J.Leban,
U.Knippschild.
Difluoro-Dioxolo-Benzoimidazol-Benzamides As Potent Inhibitors of CK1 Delta and Epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation. J.Med.Chem. V. 57 7933 2014.
Page generated: Sat Dec 12 11:14:00 2020
ISSN: ISSN 0022-2623 PubMed: 25191940 DOI: 10.1021/JM500600B |
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