Chlorine in PDB 4uay: Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S

Enzymatic activity of Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S

All present enzymatic activity of Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S:
2.7.7.7;

Protein crystallography data

The structure of Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S, PDB code: 4uay was solved by B.D.Freudenthal, S.H.Wilson, W.A.Beard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	31.27 / 1.98
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	50.867, 80.445, 55.391, 90.00, 107.69, 90.00
*R / R_free (%)*	18.4 / 24.7

Other elements in 4uay:

The structure of Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Sodium	(Na)	3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S (pdb code 4uay). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S, PDB code: 4uay:

Chlorine binding site 1 out of 1 in 4uay

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Chlorine Binding Sites List in 4uay

Chlorine binding site 1 out of 1 in the Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Dna Polymerase Beta Product Complex with A Templating Adenine and Inserted 8-Oxodgmp, 40 S within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl406 b:30.0 occ:1.00	N	A:HIS34	3.3	25.4	1.0
	CB	A:ALA32	3.4	26.6	1.0
	C	A:ALA32	3.4	26.7	1.0
	CA	A:ALA32	3.5	27.7	1.0
	CB	A:HIS34	3.5	27.2	1.0
	N	A:ILE33	3.6	21.1	1.0
	N	A:LYS35	3.7	23.3	1.0
	CD2	A:HIS34	3.8	35.3	1.0
	O	A:ALA32	3.9	22.6	1.0
	CA	A:HIS34	3.9	26.6	1.0
	CG	A:HIS34	4.0	30.8	1.0
	C	A:HIS34	4.3	26.6	1.0
	C	A:ILE33	4.3	26.7	1.0
	CG	A:LYS35	4.4	25.8	1.0
	O	A:HOH626	4.5	36.4	1.0
	CA	A:ILE33	4.6	32.2	1.0
	CB	A:LYS35	4.7	23.9	1.0
	CA	A:LYS35	4.8	21.8	1.0
	O6	D:DG1	4.9	30.3	1.0
	N	A:ALA32	4.9	27.9	1.0

Reference:

B.D.Freudenthal, W.A.Beard, L.Perera, D.D.Shock, T.Kim, T.Schlick, S.H.Wilson. Uncovering the Polymerase-Induced Cytotoxicty of An Oxidized Nucleotide Nature 2014.
ISSN: ESSN 1476-4687
DOI: 10.1038/NATURE13886

Page generated: Fri Jul 26 02:09:27 2024

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