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Atomistry » Chlorine » PDB 4ufw-4uhv » 4uh5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4ufw-4uhv » 4uh5 » |
Chlorine in PDB 4uh5: Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-DiamineProtein crystallography data
The structure of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine, PDB code: 4uh5
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uh5:
The structure of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
(pdb code 4uh5). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine, PDB code: 4uh5: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4uh5Go back to Chlorine Binding Sites List in 4uh5
Chlorine binding site 1 out
of 2 in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4uh5Go back to Chlorine Binding Sites List in 4uh5
Chlorine binding site 2 out
of 2 in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl) Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
Mono view Stereo pair view
Reference:
S.Kang,
H.Li,
W.Tang,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
2-Aminopyridines with A Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J.Med.Chem. V. 58 5548 2015.
Page generated: Sat Dec 12 11:15:35 2020
ISSN: ISSN 0022-2623 PubMed: 26120733 DOI: 10.1021/ACS.JMEDCHEM.5B00573 |
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