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Chlorine in PDB 4uwi: Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand
Enzymatic activity of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand
All present enzymatic activity of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand:
2.3.1.97;
2.3.1.97;
Protein crystallography data
The structure of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand, PDB code: 4uwi
was solved by
D.A.Robinson,
S.Brand,
N.R.Norcross,
S.Thompson,
J.R.Harrison,
V.C.Smith,
L.S.Torrie,
S.P.Mcelroy,
I.Hallyburton,
S.Norval,
L.Stojanovski,
F.R.C.Simeons,
J.A.Frearson,
R.Brenk,
A.H.Fairlamb,
M.A.J.Ferguson,
P.G.Wyatt,
I.H.Gilbert,
K.D.Read,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.0 / 1.80 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 50.789, 56.897, 141.607, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.5 / 23.1 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand
(pdb code 4uwi). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand, PDB code: 4uwi:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand, PDB code: 4uwi:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 4uwi
Go back to
Chlorine Binding Sites List in 4uwi
Chlorine binding site 1 out
of 2 in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 4uwi
Go back to
Chlorine Binding Sites List in 4uwi
Chlorine binding site 2 out
of 2 in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Pyrazole Sulphonamide Ligand within 5.0Å range:
|
Reference:
S.Brand,
N.R.Norcross,
S.Thompson,
J.R.Harrison,
V.C.Smith,
D.A.Robinson,
L.S.Torrie,
S.P.Mcelroy,
I.Hallyburton,
S.Norval,
P.Scullion,
L.Stojanovski,
F.R.C.Simeons,
D.Van Aalten,
J.A.Frearson,
R.Brenk,
A.H.Fairlamb,
M.A.J.Ferguson,
P.G.Wyatt,
I.H.Gilbert,
K.D.Read.
Lead Optimization of A Pyrazole Sulfonamide Series of Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of Cns Penetrant Compounds As Potential Treatments For Stage 2 Human African Trypanosomiasis. J.Med.Chem. 2014.
ISSN: ESSN 1520-4804
PubMed: 25412409
DOI: 10.1021/JM500809C
Page generated: Sat Dec 12 11:16:28 2020
ISSN: ESSN 1520-4804
PubMed: 25412409
DOI: 10.1021/JM500809C
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