Chlorine in PDB 4uz6: Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A

All present enzymatic activity of Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A:
3.1.1.1;

The structure of Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A, PDB code: 4uz6 was solved by M.Zebisch, E.Y.Jones, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	97.90 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.455, 69.953, 195.811, 90.00, 90.00, 90.00
R / Rfree (%)	19.455 / 23.513

The binding sites of Chlorine atom in the Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A (pdb code 4uz6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A, PDB code: 4uz6:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1454 b:60.8 occ:1.00 NH1 A:ARG218 3.7 45.9 1.0 NH2 A:ARG218 3.8 44.2 1.0 NH2 A:ARG90 3.8 52.5 1.0 CE1 A:HIS92 4.0 39.0 1.0 CZ A:ARG218 4.2 43.6 1.0 ND1 A:HIS92 4.5 37.3 1.0 NH1 A:ARG90 4.6 54.0 1.0 CZ A:ARG90 4.7 52.3 1.0

Chlorine binding site 2 out of 2 in the Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of the Wnt Deacylase Notum - Crystal Form V - Sos Complex - 1.9A within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1454 b:75.3 occ:1.00 NH2 B:ARG90 3.2 62.4 1.0 CE1 B:HIS92 3.9 38.5 1.0 NH1 B:ARG90 3.9 62.3 1.0 CZ B:ARG90 4.0 59.9 1.0 NH1 B:ARG218 4.2 51.1 1.0 ND1 B:HIS92 4.4 39.1 1.0 NH2 B:ARG218 4.7 52.2 1.0 CZ B:ARG218 4.9 49.2 1.0

S.Kakugawa, P.F.Langton, M.Zebisch, S.A.Howell, T.-H.Chang, Y.Liu, T.Feizi, G.Bineva, N.O'reilly, A.P.Snijders, E.Y.Jones, J.-P.Vincent. Notum Deacylates Wnt Proteins to Suppress Signalling Activity Nature 2015.
ISSN: ESSN 1476-4687
DOI: 10.1038/NATURE14259