Chlorine in PDB 4wph: Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation

All present enzymatic activity of Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation:
3.4.19.12;

The structure of Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation, PDB code: 4wph was solved by R.Pfoh, I.Lacdao, V.Saridakis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.92
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	92.336, 92.336, 190.283, 90.00, 90.00, 120.00
R / Rfree (%)	23.3 / 26.2

The binding sites of Chlorine atom in the Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation (pdb code 4wph). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation, PDB code: 4wph:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2001 b:89.4 occ:1.00 NE2 A:HIS792 3.4 61.7 1.0 NH2 A:ARG862 4.1 97.4 1.0 CE1 A:HIS792 4.2 61.3 1.0 CD2 A:HIS792 4.3 59.4 1.0 CE2 A:TYR791 4.4 59.0 1.0 NH1 A:ARG862 4.6 98.7 1.0 ND2 A:ASN741 4.9 65.5 1.0 CZ A:ARG862 4.9 97.0 1.0

Chlorine binding site 2 out of 4 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2002 b:74.1 occ:1.00 NE2 A:GLN821 3.5 66.5 1.0 CD A:GLN821 4.0 66.4 1.0 CG A:MET817 4.2 53.6 1.0 OE1 A:GLN821 4.2 66.2 1.0 O A:ARG816 4.4 75.7 1.0 NH1 A:ARG816 4.5 0.2 1.0 OG A:SER814 4.7 58.3 1.0 CA A:MET817 4.8 58.0 1.0 C A:ARG816 4.8 65.4 1.0 CZ A:ARG816 4.9 98.2 1.0 CB A:SER814 4.9 55.3 1.0 N A:MET817 4.9 60.8 1.0

Chlorine binding site 3 out of 4 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2003 b:82.8 occ:1.00 NH2 A:ARG854 3.7 65.1 1.0 CZ A:ARG854 4.7 67.8 1.0 NE A:ARG854 4.7 70.0 1.0

Chlorine binding site 4 out of 4 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of USP7 Ubiquitin-Like Domains in Compact Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl2001 b:90.4 occ:1.00 CE1 B:HIS792 3.9 98.9 1.0 ND2 B:ASN741 4.1 73.0 1.0 NE2 B:HIS792 4.4 99.4 1.0 NH2 B:ARG816 4.5 0.2 1.0 CE2 B:TYR791 4.7 80.7 1.0 NH2 B:ARG862 4.8 0.6 1.0

R.Pfoh, I.K.Lacdao, A.A.Georges, A.Capar, H.Zheng, L.Frappier, V.Saridakis. Crystal Structure of USP7 Ubiquitin-Like Domains with An ICP0 Peptide Reveals A Novel Mechanism Used By Viral and Cellular Proteins to Target USP7. Plos Pathog. V. 11 04950 2015.
ISSN: ESSN 1553-7374
PubMed: 26046769
DOI: 10.1371/JOURNAL.PPAT.1004950