Chlorine in PDB 4wpi: Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation

All present enzymatic activity of Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation:
3.4.19.12;

The structure of Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation, PDB code: 4wpi was solved by R.Pfoh, I.K.L.Lacdao, V.Saridakis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 3.40
Space group	P 42 21 2
Cell size a, b, c (Å), α, β, γ (°)	164.990, 164.990, 110.120, 90.00, 90.00, 90.00
R / Rfree (%)	24.1 / 28.2

The binding sites of Chlorine atom in the Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation (pdb code 4wpi). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation, PDB code: 4wpi:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2001 b:0.1 occ:1.00 NH2 A:ARG829 4.1 0.9 1.0 CB A:PHE809 4.2 0.0 1.0 CG A:PHE809 4.7 0.7 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2002 b:0.8 occ:1.00 NE A:ARG697 2.5 0.8 1.0 CD A:ARG697 3.0 0.7 1.0 CZ A:ARG697 3.2 0.9 1.0 NH2 A:ARG697 3.6 0.4 1.0 CG A:GLU779 3.9 0.3 1.0 NH1 A:ARG697 4.0 0.2 1.0 CB A:GLU779 4.0 0.3 1.0 CG A:ARG697 4.4 0.9 1.0 CB A:ARG697 4.8 0.1 1.0 CD A:GLU779 5.0 0.6 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of USP7 Ubiquitin-Like Domains in Extended Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl2001 b:0.7 occ:1.00 NH1 B:ARG788 2.5 0.4 1.0 NH1 B:ARG816 2.8 0.2 1.0 NE2 B:HIS792 3.4 0.3 1.0 CZ B:ARG788 3.6 0.5 1.0 CZ B:ARG816 3.7 0.1 1.0 CD B:ARG788 3.8 0.3 1.0 CD B:ARG816 3.9 0.7 1.0 NE B:ARG788 4.1 0.2 1.0 CG B:ARG788 4.1 0.4 1.0 NE B:ARG816 4.1 0.0 1.0 CD2 B:HIS792 4.2 0.7 1.0 OD1 B:ASN741 4.2 0.8 1.0 CE1 B:HIS792 4.4 0.4 1.0 NH2 B:ARG788 4.6 0.5 1.0 NH2 B:ARG816 4.7 0.9 1.0 CB B:ARG788 4.7 0.8 1.0 ND2 B:ASN741 4.9 0.1 1.0

R.Pfoh, I.K.Lacdao, A.A.Georges, A.Capar, H.Zheng, L.Frappier, V.Saridakis. Crystal Structure of USP7 Ubiquitin-Like Domains with An ICP0 Peptide Reveals A Novel Mechanism Used By Viral and Cellular Proteins to Target USP7. Plos Pathog. V. 11 04950 2015.
ISSN: ESSN 1553-7374
PubMed: 26046769
DOI: 10.1371/JOURNAL.PPAT.1004950