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Chlorine in PDB 4wt9: Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations

Enzymatic activity of Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations

All present enzymatic activity of Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations:
2.7.7.48;

Protein crystallography data

The structure of Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations, PDB code: 4wt9 was solved by T.E.Edwards, T.C.Appleby, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 140.370, 140.370, 92.230, 90.00, 90.00, 120.00
R / Rfree (%) 19.3 / 24.5

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations (pdb code 4wt9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations, PDB code: 4wt9:

Chlorine binding site 1 out of 1 in 4wt9

Go back to Chlorine Binding Sites List in 4wt9
Chlorine binding site 1 out of 1 in the Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Apo Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 Mutations within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl601

b:46.6
occ:1.00
 N A:ARG377 3.3 51.2 1.0
N A:ARG379 3.4 37.6 1.0
CB A:ARG377 3.6 49.8 1.0
CA A:GLY375 3.6 39.7 1.0
CB A:ARG379 3.6 33.3 1.0
C A:GLY375 3.6 40.3 1.0
CA A:ARG377 3.6 53.8 1.0
N A:GLY378 3.7 46.6 1.0
C A:ARG377 3.7 50.4 1.0
CD A:PRO376 3.7 45.0 1.0
N A:PRO376 3.8 44.6 1.0
NE A:ARG381 4.0 58.9 1.0
CA A:ARG379 4.0 36.9 1.0
O A:GLY375 4.1 37.3 1.0
NH2 A:ARG381 4.1 75.5 1.0
N A:GLY375 4.2 39.8 1.0
O A:ARG379 4.2 40.2 1.0
C A:PRO376 4.4 47.8 1.0
O A:ARG377 4.4 51.6 1.0
CG A:PRO376 4.4 48.0 1.0
C A:GLY378 4.5 40.1 1.0
C A:ARG379 4.5 37.9 1.0
CZ A:ARG381 4.5 67.9 1.0
CA A:PRO376 4.6 46.2 1.0
CA A:GLY378 4.6 42.6 1.0
OD1 A:ASP470 4.7 54.9 1.0
CG A:ARG381 4.9 45.4 1.0
OD2 A:ASP470 4.9 59.5 1.0
CD A:ARG381 5.0 50.8 1.0

Reference:

T.C.Appleby, J.Perry, E.Murakami, O.Barauskas, J.Feng, A.Cho, D.Fox Iii, D.R.Wetmore, M.E.Mcgrath, A.S.Ray, M.J.Sofia, S.Swaminathan, T.E.Edwards. Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Sat Dec 12 11:18:49 2020

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