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Chlorine in PDB 4wta: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
Enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
All present enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu, PDB code: 4wta
was solved by
T.E.Edwards,
T.C.Appleby,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.80 |
| Space group | P 65 |
| Cell size a, b, c (Å), α, β, γ (°) | 140.620, 140.620, 91.000, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.6 / 22.4 |
Other elements in 4wta:
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu also contains other interesting chemical elements:
| Manganese | (Mn) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
(pdb code 4wta). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu, PDB code: 4wta:
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu, PDB code: 4wta:
Chlorine binding site 1 out of 1 in 4wta
Go back to
Chlorine Binding Sites List in 4wta
Chlorine binding site 1 out
of 1 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Udp, MN2+ and Symmetrical Primer Template 5'-Caaaauuu within 5.0Å range:
|
Reference:
T.C.Appleby,
J.Perry,
E.Murakami,
O.Barauskas,
J.Feng,
A.Cho,
D.Fox Iii,
D.R.Wetmore,
M.E.Mcgrath,
A.S.Ray,
M.J.Sofia,
S.Swaminathan,
T.E.Edwards.
Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Sat Dec 12 11:18:50 2020
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