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Chlorine in PDB 4wtc: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
Enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
All present enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu, PDB code: 4wtc
was solved by
T.E.Edwards,
T.C.Appleby,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.75 |
| Space group | P 65 |
| Cell size a, b, c (Å), α, β, γ (°) | 141.340, 141.340, 90.800, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.8 / 22.9 |
Other elements in 4wtc:
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu also contains other interesting chemical elements:
| Manganese | (Mn) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
(pdb code 4wtc). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu, PDB code: 4wtc:
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu, PDB code: 4wtc:
Chlorine binding site 1 out of 1 in 4wtc
Go back to
Chlorine Binding Sites List in 4wtc
Chlorine binding site 1 out
of 1 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Beta Hairpin Loop Deletion in Complex with Cdp, MN2+ and Symmetrical Primer Template 5'-Agaaauuu within 5.0Å range:
|
Reference:
T.C.Appleby,
J.Perry,
E.Murakami,
O.Barauskas,
J.Feng,
A.Cho,
D.Fox Iii,
D.R.Wetmore,
M.E.Mcgrath,
A.S.Ray,
M.J.Sofia,
S.Swaminathan,
T.E.Edwards.
Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Fri Jul 26 03:05:25 2024
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