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Chlorine in PDB 4wtj: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp

Enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp

All present enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp, PDB code: 4wtj was solved by T.E.Edwards, T.C.Appleby, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.73 / 2.20
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 139.870, 139.870, 92.700, 90.00, 90.00, 120.00
R / Rfree (%) 17.6 / 21.1

Other elements in 4wtj:

The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp (pdb code 4wtj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp, PDB code: 4wtj:

Chlorine binding site 1 out of 1 in 4wtj

Go back to Chlorine Binding Sites List in 4wtj
Chlorine binding site 1 out of 1 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Aucc, Rna Primer 5'-Pgg, MN2+, and Adp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl603

b:45.3
occ:1.00
 N A:ARG377 3.0 48.5 1.0
N A:ARG379 3.3 32.7 1.0
C A:GLY375 3.4 36.0 1.0
CA A:GLY375 3.4 35.1 1.0
CB A:ARG377 3.4 48.7 1.0
CA A:ARG377 3.5 48.0 1.0
N A:PRO376 3.5 40.3 1.0
CB A:ARG379 3.5 31.8 1.0
N A:GLY378 3.5 44.9 1.0
C A:ARG377 3.6 49.3 1.0
CD A:PRO376 3.6 40.3 1.0
CA A:ARG379 3.9 32.5 1.0
O A:GLY375 4.0 34.4 1.0
N A:GLY375 4.0 33.1 1.0
NH2 A:ARG381 4.0 66.7 1.0
C A:PRO376 4.1 47.0 1.0
O A:ARG379 4.1 28.6 1.0
NE A:ARG381 4.3 58.8 1.0
CZ A:ARG381 4.3 62.1 1.0
C A:GLY378 4.3 36.7 1.0
CA A:PRO376 4.3 43.8 1.0
O A:ARG377 4.4 47.8 1.0
C A:ARG379 4.4 32.9 1.0
CA A:GLY378 4.4 40.9 1.0
CG A:PRO376 4.5 43.7 1.0
CB A:PRO376 4.8 42.5 1.0
CG A:ARG381 4.8 46.4 1.0
OD1 A:ASP470 4.8 50.1 1.0

Reference:

T.C.Appleby, J.Perry, E.Murakami, O.Barauskas, J.Feng, A.Cho, D.Fox Iii, D.R.Wetmore, M.E.Mcgrath, A.S.Ray, M.J.Sofia, S.Swaminathan, T.E.Edwards. Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Fri Jul 26 03:06:04 2024

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