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Chlorine in PDB 4wtk: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp

Enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp

All present enzymatic activity of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp, PDB code: 4wtk was solved by T.E.Edwards, T.C.Appleby, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 140.230, 140.230, 92.540, 90.00, 90.00, 120.00
R / Rfree (%) 18.4 / 22.4

Other elements in 4wtk:

The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp also contains other interesting chemical elements:

Manganese (Mn) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp (pdb code 4wtk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp, PDB code: 4wtk:

Chlorine binding site 1 out of 1 in 4wtk

Go back to Chlorine Binding Sites List in 4wtk
Chlorine binding site 1 out of 1 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations in Complex with Rna Template 5'-Agcc, Rna Primer 5'-Pgg, MN2+, and Cdp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl604

b:65.6
occ:1.00
 N A:ARG377 3.1 64.5 1.0
N A:ARG379 3.3 53.3 1.0
CB A:ARG379 3.4 49.0 1.0
CB A:ARG377 3.5 66.9 1.0
CA A:ARG377 3.5 67.1 1.0
C A:GLY375 3.6 56.0 1.0
N A:GLY378 3.6 68.1 1.0
C A:ARG377 3.6 68.0 1.0
CA A:GLY375 3.6 54.1 1.0
N A:PRO376 3.7 56.8 1.0
CD A:PRO376 3.8 58.6 1.0
CA A:ARG379 3.9 51.8 1.0
NH2 A:ARG381 3.9 80.4 1.0
O A:GLY375 4.1 54.5 1.0
O A:ARG379 4.1 51.1 1.0
N A:GLY375 4.2 51.4 1.0
C A:PRO376 4.2 60.1 1.0
NE A:ARG381 4.3 72.5 1.0
CZ A:ARG381 4.3 77.3 1.0
CG A:PRO376 4.3 57.5 1.0
O A:ARG377 4.3 66.9 1.0
C A:GLY378 4.4 57.9 1.0
C A:ARG379 4.4 52.3 1.0
CA A:PRO376 4.5 58.9 1.0
CA A:GLY378 4.5 61.8 1.0

Reference:

T.C.Appleby, J.Perry, E.Murakami, O.Barauskas, J.Feng, A.Cho, D.Fox Iii, D.R.Wetmore, M.E.Mcgrath, A.S.Ray, M.J.Sofia, S.Swaminathan, T.E.Edwards. Structural Basis For Rna Replication By the Hepatitis C Virus Polymerase To Be Published.
Page generated: Fri Jul 26 03:06:13 2024

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