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Chlorine in PDB 4x5t: Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic

Protein crystallography data

The structure of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic, PDB code: 4x5t was solved by L.Sauguet, P.J.Corringer, C.Huon, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 3.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 118.894, 132.304, 190.517, 90.00, 90.00, 90.00
R / Rfree (%) 25.4 / 27

Other elements in 4x5t:

The structure of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic also contains other interesting chemical elements:

Nickel (Ni) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic (pdb code 4x5t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic, PDB code: 4x5t:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 4x5t

Go back to Chlorine Binding Sites List in 4x5t
Chlorine binding site 1 out of 6 in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:0.0
occ:1.00
 N A:ARG85 3.3 0.6 1.0
NH1 A:ARG85 3.3 0.9 1.0
N A:PHE78 3.4 0.4 1.0
CD2 A:PHE78 3.5 0.9 1.0
CG A:ARG85 3.6 0.6 1.0
CB A:ARG85 3.8 0.7 1.0
CA A:ALA84 3.9 0.5 1.0
CB A:PHE78 3.9 0.5 1.0
CD A:ARG85 4.0 0.9 1.0
C A:ALA84 4.1 0.1 1.0
CA A:ARG77 4.2 0.9 1.0
CG A:PHE78 4.2 0.7 1.0
CA A:ARG85 4.2 0.0 1.0
CB A:ALA84 4.2 0.1 1.0
CG2 A:VAL81 4.2 0.5 1.0
C A:ARG77 4.2 0.0 1.0
CA A:PHE78 4.2 0.5 1.0
CZ A:ARG85 4.4 0.4 1.0
CE2 A:PHE78 4.5 0.3 1.0
NE A:ARG85 4.6 0.1 1.0
O A:PHE78 4.6 0.0 1.0
CB A:ARG77 4.6 0.8 1.0
CG A:ARG77 4.9 0.1 1.0
C A:PHE78 5.0 1.0 1.0

Chlorine binding site 2 out of 6 in 4x5t

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Chlorine binding site 2 out of 6 in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl502

b:0.1
occ:1.00
 O B:PRO74 3.2 0.6 1.0
NH2 B:ARG85 3.3 1.0 1.0
N B:ILE76 3.6 0.6 1.0
O B:ILE76 3.9 0.3 1.0
CB B:ILE76 4.2 0.0 1.0
C B:PRO74 4.3 0.8 1.0
CA B:GLU75 4.4 0.7 1.0
CG2 B:ILE73 4.4 0.4 1.0
CA B:ILE76 4.4 0.5 1.0
OE1 B:GLU104 4.4 0.0 1.0
CG1 B:ILE76 4.5 0.4 1.0
C B:GLU75 4.5 0.3 1.0
OH B:TYR102 4.5 0.8 1.0
CD1 B:LEU45 4.5 0.0 1.0
CZ B:ARG85 4.5 0.8 1.0
C B:ILE76 4.6 0.7 1.0
N B:GLU75 4.8 0.5 1.0
CZ B:TYR102 4.9 0.4 1.0

Chlorine binding site 3 out of 6 in 4x5t

Go back to Chlorine Binding Sites List in 4x5t
Chlorine binding site 3 out of 6 in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl503

b:0.0
occ:1.00
 NH1 B:ARG85 3.1 0.5 1.0
N B:ARG85 3.2 0.3 1.0
CG B:ARG85 3.4 0.2 1.0
CD2 B:PHE78 3.6 0.3 1.0
N B:PHE78 3.6 0.2 1.0
CB B:ARG85 3.7 0.6 1.0
CD B:ARG85 3.8 0.2 1.0
CA B:ALA84 3.9 0.2 1.0
CA B:ARG85 4.0 0.2 1.0
C B:ALA84 4.1 1.0 1.0
CB B:ALA84 4.1 0.7 1.0
CB B:PHE78 4.1 0.4 1.0
CZ B:ARG85 4.1 0.8 1.0
CA B:ARG77 4.3 0.7 1.0
CG B:PHE78 4.3 0.9 1.0
NE B:ARG85 4.4 0.9 1.0
C B:ARG77 4.4 0.7 1.0
CG2 B:VAL81 4.4 0.6 1.0
CE2 B:PHE78 4.4 0.3 1.0
CA B:PHE78 4.5 0.0 1.0
CB B:ARG77 4.8 0.9 1.0
O B:PHE78 4.9 1.0 1.0
O B:ILE76 5.0 0.3 1.0

Chlorine binding site 4 out of 6 in 4x5t

Go back to Chlorine Binding Sites List in 4x5t
Chlorine binding site 4 out of 6 in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl502

b:0.6
occ:1.00
 N C:ARG85 3.2 99.8 1.0
NH1 C:ARG85 3.4 92.4 1.0
N C:PHE78 3.5 94.1 1.0
CD2 C:PHE78 3.6 90.8 1.0
CG C:ARG85 3.6 94.7 1.0
CB C:ARG85 3.8 95.5 1.0
CA C:ALA84 3.9 0.8 1.0
CB C:PHE78 3.9 92.9 1.0
CD C:ARG85 4.0 92.6 1.0
C C:ALA84 4.1 0.5 1.0
CA C:ARG85 4.1 99.4 1.0
CG2 C:VAL81 4.2 98.9 1.0
CG C:PHE78 4.2 91.4 1.0
CB C:ALA84 4.2 0.2 1.0
CA C:ARG77 4.2 95.6 1.0
CA C:PHE78 4.3 94.4 1.0
C C:ARG77 4.3 95.0 1.0
CZ C:ARG85 4.4 93.0 1.0
CE2 C:PHE78 4.5 90.9 1.0
O C:PHE78 4.6 98.9 1.0
NE C:ARG85 4.6 93.2 1.0
CB C:ARG77 4.7 98.8 1.0
C C:PHE78 5.0 97.5 1.0
CG C:ARG77 5.0 0.9 1.0

Chlorine binding site 5 out of 6 in 4x5t

Go back to Chlorine Binding Sites List in 4x5t
Chlorine binding site 5 out of 6 in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl503

b:0.0
occ:1.00
 O C:PRO74 3.3 0.0 1.0
NH2 C:ARG85 3.3 94.5 1.0
N C:ILE76 3.6 0.9 1.0
O C:ILE76 3.9 95.2 1.0
CA C:GLU75 4.3 0.7 1.0
CB C:ILE76 4.4 98.9 1.0
C C:PRO74 4.4 0.1 1.0
OE1 C:GLU104 4.4 0.2 1.0
CA C:ILE76 4.4 99.0 1.0
CG2 C:ILE73 4.5 0.3 1.0
C C:GLU75 4.5 0.9 1.0
CZ C:ARG85 4.5 93.0 1.0
OH C:TYR102 4.5 0.8 1.0
CG1 C:ILE76 4.6 0.2 1.0
C C:ILE76 4.6 96.3 1.0
CD1 C:LEU45 4.7 0.8 1.0
N C:GLU75 4.8 0.1 1.0
CZ C:TYR102 4.9 0.2 1.0

Chlorine binding site 6 out of 6 in 4x5t

Go back to Chlorine Binding Sites List in 4x5t
Chlorine binding site 6 out of 6 in the Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Alpha 1 Glycine Receptor Transmembrane Structure Fused to the Extracellular Domain of Glic within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl502

b:0.0
occ:1.00
 N E:PHE78 3.3 0.9 1.0
N E:ARG85 3.4 0.8 1.0
NH1 E:ARG85 3.4 0.0 1.0
CD2 E:PHE78 3.4 1.0 1.0
CG E:ARG85 3.7 0.7 1.0
CB E:PHE78 3.7 0.2 1.0
CB E:ARG85 3.8 0.3 1.0
CG E:PHE78 4.0 0.6 1.0
CG2 E:VAL81 4.0 0.5 1.0
CA E:ALA84 4.0 0.4 1.0
CD E:ARG85 4.0 0.6 1.0
CA E:PHE78 4.1 0.6 1.0
C E:ARG77 4.2 0.7 1.0
CA E:ARG85 4.2 0.6 1.0
C E:ALA84 4.2 0.4 1.0
CA E:ARG77 4.2 0.8 1.0
CB E:ALA84 4.3 0.9 1.0
CE2 E:PHE78 4.4 0.7 1.0
O E:PHE78 4.4 0.5 1.0
CZ E:ARG85 4.4 0.2 1.0
NE E:ARG85 4.7 0.5 1.0
CB E:ARG77 4.7 0.3 1.0
C E:PHE78 4.8 0.2 1.0

Reference:

G.Moraga-Cid, L.Sauguet, C.Huon, L.Malherbe, C.Girard-Blanc, S.Petres, S.Murail, A.Taly, M.Baaden, M.Delarue, P.J.Corringer. Allosteric and Hyperekplexic Mutant Phenotypes Investigated on An Alpha 1 Glycine Receptor Transmembrane Structure Proc.Natl.Acad.Sci.Usa 2015.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.1417864112
Page generated: Sat Dec 12 11:19:39 2020

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