Chlorine in PDB 4x90: Crystal Structure of Lysosomal Phospholipase A2

The structure of Crystal Structure of Lysosomal Phospholipase A2, PDB code: 4x90 was solved by A.Glukhova, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 1.84
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	62.806, 91.151, 100.266, 78.13, 88.46, 88.50
R / Rfree (%)	15.4 / 17.3

The binding sites of Chlorine atom in the Crystal Structure of Lysosomal Phospholipase A2 (pdb code 4x90). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Lysosomal Phospholipase A2, PDB code: 4x90:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Crystal Structure of Lysosomal Phospholipase A2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Lysosomal Phospholipase A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl406 b:41.4 occ:1.00 ND1 A:HIS347 3.1 25.8 0.3 N A:GLN348 3.4 27.0 1.0 CD2 A:HIS347 3.4 26.1 0.7 O A:HOH527 3.5 37.0 1.0 NE2 A:GLN294 3.6 31.3 1.0 CA A:HIS347 3.8 26.2 0.7 CA A:HIS347 3.8 26.3 0.3 CG A:HIS347 3.9 25.6 0.3 CB A:HIS347 4.0 25.4 0.3 CB A:GLN294 4.0 23.3 1.0 CB A:HIS347 4.0 25.4 0.7 CG A:GLN348 4.0 40.4 1.0 CE1 A:HIS347 4.0 26.2 0.3 CG A:HIS347 4.0 25.6 0.7 NE2 A:GLN348 4.1 48.2 1.0 C A:HIS347 4.1 26.1 1.0 CB A:GLN348 4.2 33.1 1.0 CG A:GLN294 4.2 25.6 1.0 CA A:GLN348 4.4 29.2 1.0 CD A:GLN294 4.4 28.8 1.0 CA A:GLN294 4.5 21.4 1.0 CD A:GLN348 4.6 46.3 1.0 NE2 A:HIS347 4.6 26.6 0.7 N A:GLN294 4.9 20.0 1.0

Chlorine binding site 2 out of 4 in the Crystal Structure of Lysosomal Phospholipase A2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Lysosomal Phospholipase A2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl406 b:40.6 occ:1.00 N B:GLN348 3.3 30.4 1.0 ND1 B:HIS347 3.3 31.9 0.3 NE2 B:GLN294 3.6 32.4 1.0 CD2 B:HIS347 3.8 34.2 0.7 CA B:HIS347 3.8 32.0 0.7 CA B:HIS347 3.8 31.6 0.3 CG B:GLN348 3.8 42.5 1.0 CB B:GLN294 3.9 25.0 1.0 CB B:HIS347 3.9 30.6 0.3 NE2 B:GLN348 4.0 49.8 1.0 CB B:HIS347 4.0 31.2 0.7 CB B:GLN348 4.0 35.4 1.0 C B:HIS347 4.0 30.4 1.0 CG B:HIS347 4.0 31.1 0.3 CG B:GLN294 4.1 27.1 1.0 CG B:HIS347 4.1 32.7 0.7 CA B:GLN348 4.2 33.0 1.0 CE1 B:HIS347 4.3 31.9 0.3 CD B:GLN294 4.4 28.6 1.0 CD B:GLN348 4.4 47.2 1.0 CA B:GLN294 4.4 23.1 1.0 N B:GLN294 4.9 22.4 1.0 NE2 B:HIS347 4.9 35.2 0.7 O B:GLN348 4.9 27.1 1.0

Chlorine binding site 3 out of 4 in the Crystal Structure of Lysosomal Phospholipase A2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Lysosomal Phospholipase A2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl406 b:32.5 occ:1.00 ND1 C:HIS347 3.2 25.3 0.3 N C:GLN348 3.3 24.9 1.0 NE2 C:GLN294 3.4 25.9 1.0 CG C:GLN348 3.8 35.2 1.0 NE2 C:GLN348 3.8 43.3 1.0 CB C:GLN294 3.8 21.3 1.0 CA C:HIS347 3.9 25.5 0.7 CA C:HIS347 3.9 25.2 0.3 CD2 C:HIS347 3.9 28.0 0.7 CB C:GLN348 3.9 28.9 1.0 CG C:GLN294 4.0 22.7 1.0 CB C:HIS347 4.0 24.6 0.3 CG C:HIS347 4.0 24.8 0.3 CB C:HIS347 4.0 25.6 0.7 C C:HIS347 4.1 24.8 1.0 CE1 C:HIS347 4.2 25.4 0.3 CA C:GLN348 4.2 25.9 1.0 CD C:GLN294 4.2 24.3 1.0 CG C:HIS347 4.2 26.5 0.7 CD C:GLN348 4.3 39.8 1.0 CA C:GLN294 4.4 19.8 1.0 O C:GLN348 4.9 21.8 1.0 N C:GLN294 4.9 19.1 1.0

Chlorine binding site 4 out of 4 in the Crystal Structure of Lysosomal Phospholipase A2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Lysosomal Phospholipase A2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl407 b:47.0 occ:1.00 N D:GLN348 3.1 28.0 1.0 NE2 D:GLN294 3.5 32.0 1.0 CG D:GLN348 3.7 40.6 1.0 CA D:HIS347 3.7 27.6 0.7 CA D:HIS347 3.8 27.6 0.3 CB D:GLN294 3.8 24.7 1.0 CD2 D:HIS347 3.8 27.3 0.7 CB D:GLN348 3.8 33.8 1.0 CB D:HIS347 3.9 26.6 0.7 C D:HIS347 3.9 27.2 1.0 NE2 D:GLN348 3.9 50.2 1.0 CG D:GLN294 4.0 27.6 1.0 CB D:HIS347 4.0 26.7 0.3 CA D:GLN348 4.0 30.1 1.0 CG D:HIS347 4.1 26.7 0.7 ND1 D:HIS347 4.2 27.0 0.3 CD D:GLN294 4.3 30.5 1.0 CA D:GLN294 4.3 22.4 1.0 CD D:GLN348 4.3 45.0 1.0 CG D:HIS347 4.5 26.7 0.3 O D:GLN348 4.7 24.3 1.0 N D:GLN294 4.8 20.6 1.0 C D:GLN348 4.9 27.2 1.0 NE2 D:HIS347 5.0 27.5 0.7

A.Glukhova, V.Hinkovska-Galcheva, R.Kelly, A.Abe, J.A.Shayman, J.J.G.Tesmer. Structure and Function of Lysosomal Phospholipase A2 and Lecithin:Cholesterol Acyltransferase Nat Commun 2015.
ISSN: ESSN 2041-1723
DOI: 10.1038/NCOMMS7250